PathHunter® Activated GPCR Endocytosis Assays

PathHunter® Activated GPCR Endocytosis Assays
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DiscoveRx Corporation

PathHunter® Activated GPCR Internalization Assays provide a quantitative measurement of internalized GPCR protein localized to the endocytic compartment and let you monitor the cellular fate of unl...read more

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Description

 

PathHunter® Activated GPCR Internalization Assays provide a quantitative measurement of internalized GPCR protein localized to the endocytic compartment and let you monitor the cellular fate of unlabeled, arrestin-bound GPCRs in live cells. Unlike other imaging or antibody-based internalization technologies, PathHunter assays are simple, non-radioactive chemiluminescent assays that are amerable to high throughput screening.

Product Features:

  • Over 60 Gi, Gs, and Gq coupled receptors available
  • Pre-validated, stable cell lines expressing native, untagged receptors
  • Measure of activated & internalized GPCRs targeted to early endosomes
  • Quantitative gain-of-signal assay
  • No antibodies, imaging or radioactivity
  • HTS-friendly format

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