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Status:
Advanced Reviewer
Member since: 2013
Organization: National Institute Of Nutrition (nin)
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- Ease of use
- After sales service
- Value for money
Application Area: KO Studies For p53
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Review date: 23 Dec 2013 | p53 Knockout Rat
Nomenclature: SD- Tp53 tm1sage
Genotype: Homozygous
Description
This model contains a bi-allelic 14 base pair deletion within exon 3 of the most commonly mutated gene in human cancers, Tp53 (Tumor protein p53). This deletion causes a frameshift in the coding region, resulting in a premature termination codon at the end of exon 3.
Additional Information on the p53 Knockout
p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Homozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment.
Characteristics of the p53 Knockout
Total loss of protein via Western blot
Research Applications
Early carcinogenicity screening
Chemopreventive/Chemotherapeutic screening
p53 function studies
Diet
Purina #5008
