Roche NimbleGen provides the most sensitive and specific DNA Methylation microarrays and services on the market. Methylated DNA regions are accurately mapped using a combination of affinity-based enrichment, such as Methylated DNA Immunoprecipitation (MeDIP) or the Methylated CpG Island Recovery Assay (MIRA), followed by microarray analysis. Roche NimbleGen offers several types of DNA
Methylation arrays for a variety of organisms to meet your specific research needs:
• Whole-Genome Designs cover all unique genomic regions in single arrays or multi-array sets and offer unbiased, comprehensive genome coverage for the most complete data sets possible.
• Promoter Designs cover important regulatory regions. Deluxe Promoter arrays offer extensive, single-slide coverage of those regions including gene and miRNA promoters, and CpG islands, while promoter arrays cover only gene promoters.
• Targeted Designs focus on CpG islands, RefSeq genes, ENCODE regions (up to 30 Mb), promoters of non-coding RNAs or the HOX clusters.
• Custom Designs allow researchers to specify their regions of interest for a fine-tiling approach or design their own targeted probes for a tailored array solution.