The TA Instruments Nano-Series calorimeters represent the highest sensitivity and unmatched flexibility for the investigation of biological samples. The Nano ITC is focused on the measurement of ligand binding and reaction kinetics, with increased baseline stability and more tolerance to environment temperature fluctuations. New heat sensing architecture ensures the highest data quality for reproducible results using the new easy-to-use NanoAnalyze data analysis software. The Nano DSC is specifically designed to determine the thermal stability and heat capacity of proteins and other macromolecules in dilute solution, with versatility to allow the screening of ligands and pressure perturbation measurement