Mustang® Chromatography Capsules and Cartridges by Pall Life Sciences Products - Biopharmaceutical Division

Combining high-capacity ion-exchange Mustang membranes, with a unique 16-layer open pleat design, results in high-flow rate, high-capacity, single-use, versatile, range of pleated products that can be used for a wide range of applications. This 16-layer construction is held constant from the laboratory scale Mustang coin unit to the largest industrial process scale capsule, ensuring constant chromatography bed depth in all formats. Mustang E capsules use 3 layers of a standard pleat format membrane to remove endotoxin from process feedstreams. The 3-layer construction is held constant from the Mustang E Acrodisc format to the largest industrial process scale capsule.

The ease of linear scale up ensures a shortened process development time by significantly reducing the re-optimization required between scale up steps. These units are specifically designed to be single-use. This eliminates cleaning and the costs associated with cleaning validation. Mustang capsules are fully self contained units that connect directly into a system using 18 mm (1.5 in.) sanitary flange connectors. Mustang cartridges require the use of a Code 7 housing which requires cleaning and reassembly after each use.

Mustang Q Membrane
Mustang Q membrane is an anion exchange support with pendant quaternary amine functional groups in a cross-linked polymeric coating on a 0.8 µm pore size membrane. This gives high dynamic capacities for high molecular weight products such as DNA, plasmids or even particles as large as viruses.

Mustang S Membrane
Mustang S membrane is a cation exchange support with pendant sulfonic functional groups in a cross-linked polymeric coating on a 0.8 µm pore size membrane. This gives high dynamic capacities for high molecular weight products such as IgG, Factor VIII and some viruses.

Mustang E Membrane
Mustang E membrane is a highly cross-linked quaternized amine charge polymer coating based on polyethyleneimine on a 0.2 µm pore size membrane. This gives very high dynamic capacities, under selected conditions for the removal of endotoxin from process feedstreams, buffers and water

Features and Benefits

• Binding Efficiency — Charged biomolecules are readily bound in a single pass.
• Speed — High-flow rates enable the processing of large volumes in less than a single working shift. Mustang units typically operate at flow rates between 10 to 40 membrane volumes per minute, making them much faster than conventional columns which typically operate at 0.5 column volumes per minute.
• Scalability — A full range of sizes accommodates the different volumes and capacities required in BioPharmaceutical processing.
• Convenience — Ready to use, autoclavable and disposable to eliminate potential packing, cleaning, validation and cross-contamination issues.
• Flexiblity — Available in capsule or cartridge format.
• Cost — Lower operating costs and capital investment compared to conventional columns that need validated packing and cleaning.

High Quality Standards

• Manufactured to high quality assurance standards in accordance with ISO 9000
• Membrane lots tested for dynamic protein binding capacity, and peak position using standard proteins
• Identified by lot number and a unique serial number for complete traceability of manufacturing history, satisfying stringent QC/QA requirements
• Supplied with Certificate of Analysis to confirm the quality and quality control of Pall
• Meets USP Biological reactivity tests in vivo in accordance with USP Class VI 50 ºC and all materials listed in Drug Master File submitted to the FDA

Comprehensive Validation

• Extensive validation to ensure consistent and reliable performance
• A comprehensive validation guide is available for each of the membrane chemistries, Q, S and E on request.