MultiScreen Solubility Filter Plates by Merck

"Unlike plates with hydrophilic membranes, which usually leak profusely if the samples in the wells contain surfactants like SDS, these plates did not leak at all when 10%SDS was added and incubated for hours [and still allowed the soluble portion of my lysates to filter through with good recovery] Pre-wetting the wells with 30% ethanol increased the filtration rate but, even without pre-wetting, my aqueous suspensions filtered through the membranes fairly quickly without needing to add any organic solvents. The well volume is 0.5ml, slightly larger than the typical 96 well [~300ul], is another nice feature. Interestingly, the same manufacturer has a deep-well version [~2ml/well] made with the same materials but every time I tried to use those for the same application, they leaked badly so I ended up having to adapt my protocol to the smaller volume. I found it works very nicely so now I am a big fan of those plates!"