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DSC directly measures the enthalpy (ΔH) and temperature (Tm) of thermally induced structural transitions in solution. This information gives valuable insights into factors that stabilize or destabilize proteins, nucleic acids, micellar complexes and many other macromolecular systems, alone or as complexes.
This information can be used to develop purification and formulation strategies, predict shelf lives, and characterize and evaluate protein constructs or other biotherapeutic entities. In addition, ligand affinities to a protein target in small molecule drug discovery programs can be ranked rapidly.
The MicroCal VP-Capillary DSC system has an active cell volume of 130 µl, allowing for thermodynamic measurements of precious samples (sample concentrations of about 0.2 mg/ml are typically needed). The system has a standard 96-well plate format for high capacity and loading ease, and up to six 96-well plates can be stored in thermostatically controlled drawers.
The fully integrated autosampler enables running of up to 50 samples per day, with all filling, injection, and cell cleaning functions fully automated for walk-away operation. The system is setup and controlled by the VPViewer control software, and data analysis is performed with MicroCal-enabled Origin software.
MicroCal VP-Capillary DSC System Features:
- Industry-proven stability-indicating technique.
- Direct measurement of biomolecular stability in solution.
- Study molecules in their native state without labeling. Can be used with solutions that interfere with optical methods including turbid or colored solutions or particulate suspensions.
- Provides insights into mechanisms of unfolding and refolding.
- Matched capillary cells provide fast scan rates and fast temperature equilibration.
- Nonreactive Tantalum 61 cells for excellent chemical resistance and to ensure inertness when working with proteins and other biomolecules.
- Minimal assay development needed.
- Screen up to 50 sample/day with unattended operation
- Standard 96-well plate format for high capacity and loading ease. Up to six well plates can be stored in thermostatically controlled drawers.
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