A low-noise multi-electrode array system for in vitro extracellular electrophysiology. The MED64 is a user-friendly multi-electrode array (MEA) system for stimulation and recording of field potentials (extracellular signals) from different areas within a biological sample over hours, days, weeks and even months.

Acute or cultured biological preparations are placed or grown directly on a grid of 64 planar microelectrodes, which serve a dual purpose of stimulus-delivery and signal recording.

The unique construction of the system eliminates the need for cumbersome and expensive equipment used in conventional electrophysiology, including a faraday cage, anti-vibration table, micromanipulators, and even the puller and glass microelectrodes.