Mantra Quantitative Pathology Workstation by PerkinElmer, Inc.

Mantra is a compact workstation where a researcher can phenotype immune cells in situ in solid tumors using multiplexed biomarkers. Unlike existing flow cytometry and next generation sequencing methods which can phenotype and quantify immune cells in homogenized samples, Mantra similarly does this using images of FFPE tissue sections, while maintaining tissue architecture and morphology. This provides spatial information which could lead to a better understanding of the role and types of immune cells within both the tumor and the tumor microenvironment so that new cancer immunotherapy treatments may be identified and researched.

The Mantra is an integrated workstation incorporating multispectral imaging technology, novel image acquisition and inForm analysis software. It can be used with a variety of stains including PerkinElmer's Opal™ reagent kits. The Mantra system is a part of PerkinElmer’s cancer immunology portfolio which includes staining reagents, imaging systems, and image analysis software.


Features & Benefits:

• Separates up to eight labels simultaneously enabling more robust biomarker quantification to support multiplexed analysis
• Mantra Snap software for integrated data transfer to inForm analysis software saving time
• Reduces autofluorescence using PerkinElmer's proprietary Autofluorescence Reduction Technology (ART™)
• Pathology Views™ for visualization of fluorescence imagery in a traditional brightfield mode (H&E and DAB)
• Automated objective and filter cube changing for quicker data results Expanded NIR imaging range to 750 nm for use with dyes such as Alexa Fluor 750 and CY7
• Small footprint that fits on any benchtop