High-resolution separations of peptides and tRNA molecules: LiChrospher® WP 300 RP-18 is a highly selective and reliable HPLC column for the separation of peptides and low molecular weight proteins. LiChrospher® WP 300 RP-18 enables the tailing-free separation of basic compounds and is excellently suited for the separation of tRNA molecules. High recovery rates are achieved, especially in the case of highly hydrophobic peptides. In addition, the same selectivity of LiChrospher® WP 300 RP-18 of 5, 12 and 15 µm guarantees non-problematic preparative up-scaling.