Enabling LC/MSn high-precision mass analysis, Shimadzu's LCMS-IT-TOF is a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and human health research, and ideal for applications in forensics, drug development, and environmental chemistry. Coupling atmospheric pressure ionization with Ion-Trap (IT) and Time-of-Flight (TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy and high mass resolution (10,000 at 1000 m/z) independent of MS mode.
The LCMS-IT-TOF has been designed to maximize sensitivity and selectivity by optimizing the ion transport to the TOF analyzer and redefining the capability of the quadrupole ion trap. The ion trap is used to focus ions before ejection into the TOF as well as supporting MSn analysis with effective precursor ion selection capabilities (resolution > 1,000 at 1,000 m/z).
The LCMS-IT-TOF allows more qualitative information about a sample to be collected in a single run, enabling researchers and scientists to:
• Elucidate structures of new molecules
• Identify impurities and contaminants
• Analyze metabolites and biomarkers to evaluate biological pathways
• Predict accurate structural details
• Obtain high-sensitivity detection of low concentration samples
To accomplish these objectives, the LCMS-IT-TOF incorporates a host of new technologies and enhancements, including:
Compressed Ion Injection" (CII) (patented)
The CII method makes it possible to control the accumulation of ions before they are introduced into the ion trap. Adopted for the LCMS-IT-TOF, it effectively couples the LC system to the MS, dramatically increasing sensitivity.
Ballistic Ion Extraction (BIE) (patented)
The use of BIE accelerates ions into the TOF instantly, and combined with the Dual-Stage Reflectron (DSR) (patented), achieves faster, more stable, and higher resolution spectra.
Temperature Control of the Flight Tube
In concert with the localized ion due to BIE from the QIT and the 10bit high-speed transient recorder, the temperature control mechanism of the flight tube enables extended stability in mass accuracy.
High-speed Ion Polarity Switching
Utilizing a newly developed, accurate and stable power supply, in combination with an innovative high-voltage switch, allows for polarity switching in only 0.1 sec or less.