Bioneer’s production facilities can accommodate large scale oligonucleotide synthesis orders ranging from milligrams to tens of grams of the purest DNA and RNA oligos, including both standard and modi...read more
Bioneer’s production facilities can accommodate large scale oligonucleotide synthesis orders ranging from milligrams to tens of grams of the purest DNA and RNA oligos, including both standard and modified. A large portion of our bulk oligo customers are involved in research requiring antisense oligos, which has opened the door to new approaches in the development of pharmaceuticals and target validation. Some of the frequently used modifications are:
• Phosphorothioates and Chimeric Oligos: General oligonucleotides are subject to rapid degradation by nucleases. Therefore, oligos for antisense application are usually synthesized with a phosphorothioate bond modification to make them resistant to nuclease activity. In phosphorothioates, a sulfur atom replaces a binding oxygen in the oligo phosphate backbone.
• 2' O-Methyl RNA oligos: 2' O-Methyl RNA increases nuclease stability and affinity of the antisense oligo to the target RNA.
Write a review
Sharing your experience will help scientists like you. Achieve Reviewer Status and Win an iPad air (All reviews published will be entered into the next drawing on March 30th 2014).
Join the Global SelectScience Community Today! It’s FREE!
Helping you make informed decisions about the latest lab products and technologies:
Be the first to learn about new technologies
10,000+ trusted product reviews from your peers
Compare 500,000 products and manufacturers
Get exclusive buying tips from experts
Find solutions fast: 10,000+ Application Notes, Webinars and Videos
Connect with 250,000 scientists... All in one place!