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Description
The Caliper Life Sciences LabChip EZ Reader is a breakthrough benchtop instrument which facilitates kinase testing and other enzyme screening and profiling. When combined with ProfilerPro kits, a low cost, turn-key solution of lab-bench kinase panel profiling is provided. LabChip assays are separations-based, so the quality of results exceeds what is achievable in homogenous, well-based assays. The LabChip EZ Reader runs kinase and enzymatic assays with a 4-Sipper microfluidics chip.
Utilizing Caliper’s widely adopted mobility shift microfluidics assay technology, the LabChip EZ Reader analyzes kinase activity by ‘sipping’ stopped reactions from 96 or 384 well microtitre plates. Caliper’s Mobility Shift Assay technology is designed for in-vitro enzyme assays aimed at the drug discovery process. It combines the advantages of capillary electrophoresis and microfluidics providing direct measurement of substrate and product, rapid assay development and real time kinetic reads.
The EZ Reader is the perfect platform for running kinase profiling with the Caliper ProfilerPro Kits. ProfilerPro Kinase Profiling kits consist of matched pairs of 384 well kinase assay and plates complete with substrates. The assay plates each contain 24 different kinases, pre-dispensed and frozen. The substrate plates contain the appropriate fluorescent labeled peptides and ATP.
Using LabChip EZ Reader researchers can monitor enzyme reactions and kinase inhibitors over time, resulting in more detailed data resulting in using less reagents. The advantages of microfluidics technology with real time kinetic analysis include: simplified and accelerated assay development and optimization, calculation of Km and Ki values from initial rates, and determination of enzyme linearity.
Reviews
Melissa Porter Status: See all reviews Member since 2013 Organization: UNC School of Pharmacy Read more » | RATING: 3.3 
"Great for end point read and kinetics. We use it for screening and characterizing compounds. The only problem is that chips can be finicky."   |
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| Catherine Simpson Status: See all reviews Member since 2013 Organization: UNC Chapel Hill Read more » | RATING: 4.0
"I love the lap chip technology. It's an effective real time assay. Our center has screened over 5 targets using the Lab Chip technology." |
| vamshikrishna Tulasi Status: See all reviews Member since 2012 Organization: Argenta discovery Read more » | RATING: 4.7
"Lab chip reader covers new trends in enzyme targeted drug discovery where we can detect amount of substrate and product conversion with mobility shift assay. This technology covers prioritising the selective compounds in typical kinase inhibitors. In this amazing piece of equipment we can detect koff and kon rates specifically to choose the inhibitors to accelerate small molecules into next phase of drug discovery." |
| Laura Lingardo Status: See all reviews Member since 2012 Organization: Pfizer Read more » | RATING: 5.0
"Easy to use with moderately high thorughput. Gives very accurate and reproducible results." |
| Matthew Falk Status: See all reviews Member since 2012 Organization: Pfizer Read more » | RATING: 4.3
"High quality data and very sensitive. Reproducible data, easy data output. Easy for beginners to use." |
| Ai Ching Wong Status: See all reviews Member since 2011 Organization: Cancer Research Technology Read more » | RATING: 4.0
"Real time measurements allows faster assay development and better understanding of enzyme kinetics. However the chips are expensive and a sizeable chunk of work is needed to fully utilise a chip." |
| Rosemary Burke Status: See all reviews Member since 2011 Organization: ICR Read more » | RATING: 3.6
"When all is working well this piece of equipment really helps our kinase research but maybe needs to be simplified to make maintenance easier." |
| Rita Lim-Wilby Status: See all reviews Member since 2011 Organization: Carnabio Usa Read more » | RATING: 4.6
"best machine for specific and direct monitoring of analytes." |
| Bill Janzen Status: See all reviews Member since 2010 Organization: UNC-Chapel Hill Read more » | RATING: 4.0
"Highest quality data available. Limited targets." |
| Lihong Shi Status: See all reviews Member since 2011 Organization: Takeda Read more » | RATING: 3.6
"This product produces high quality results." |
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