IRDye 800CW RGD Optical Probe is a near-infrared labeled BrightSite™ imaging agent specifically designed to target the overexpression of integrins on tumors.
Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. The recognition motif, RGD (Arg-Gly-Asp), is a tripeptide sequence used to bind integrin receptors including αvβ3. Interest in using a labeled RGD peptide ligand for the study and/or monitoring of diseases related to the αvβ3 receptor over expression is increasing. Several groups have labeled RGD successfully with fluorescent dyes for in vitro and in vivo imaging.
Receive your quote directly from LI-COR Biosciences.