IRDye 680RD RGD and IRDye 800CW RGD Optical Probes are near-infrared labeled BrightSite™ imaging agents specifically designed to target the overexpression of integrins on tumors.
Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. The recognition motif, RGD (Arg-Gly-Asp), is a tripeptide sequence used to bind integrin receptors including αvβ3. Interest in using a labeled RGD peptide ligand for the study and/or monitoring of diseases related to the αvβ3 receptor over expression is increasing. Several groups have labeled RGD successfully with fluorescent dyes for in vitro and in vivo imaging.
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