IRDye® 800CW 2-DG Optical Probe

IRDye® 800CW 2-DG Optical Probe

LI-COR Biosciences

Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using glucose analo...read more

Request Pricing





Receive your quote directly from LI-COR Biosciences for IRDye® 800CW 2-DG Optical Probe

Description

 

Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using glucose analogues such as 18F-2-deoxy-D-glucose (18FDG) to visualize primary tumors and their metastasis. Radiolabeled 2-deoxy-D-glucose (2-DG) is generally impractical for use in small animal studies of cancer biology. Fluorophore-labeled variants of 2-deoxy-D-glucose have been used with varying degrees of success (O’Neil et al., Lloyd et al., Cheng et al.). 

IRDye® 800CW 2-DG is a fluorescent optical imaging agent that has been shown to be reactive with implanted tumors derived from a number of cell lines including A431, SW620, 3T3-L1, and PC3LMN4. The optical agent exhibits the expected dose response with increasing concentrations of the agent in both cell based and animal experiments. Uptake of the agent can be effectively blocked with either unlabeled 2-DG or glucose, confirming its specificity. Confocal microscopy demonstrated conclusively that IRDye® 800CW 2-DG is taken up by the cell and localized in the cytoplasm. While the exact mechanism of IRDye® 800CW 2-DG uptake is not known, there is strong evidence for the involvement of the GLUT transporter system.

Feedback

Request info

To:LI-COR Biosciences
From:
Please contact me / call me with the IRDye® 800CW 2-DG Optical Probe,

I am looking to purchase in /

.
About you

Write a review

Sharing your experience will help scientists like you. Achieve Reviewer Status and Win an iPad air (All reviews published will be entered into the next drawing on May 30th 2014).

  
Your Email

 



Ease of use

After sales services

Value for money

WATCH:
The benefits of becoming a reviewer
Share your opinions...()
HINTS & TIPS
Give reasons for the star ratings you have awarded for each area.
Would you recommend this to a colleague?
What would you like to have known about equipment and consumables before you purchased?



Why make an enquiry with SelectScience?

  • EASY It’s quick and simple to do
  • FAST Your enquiry will be delivered straight to the manufacturer
  • FREE You’re under no obligation
  • SECURE We only pass your details on to trusted suppliers at your request
  • SAVE TIME Submit your details once and make multiple enquiries
SelectScience Trusted Banner