IonWorks® Quattro Automated Patch Clamp System

IonWorks® Quattro Automated Patch Clamp System
 3.6/5.0 (4 reviews)

Molecular Devices®

Molecular Devices Introduces IonWorks Quattro Automated Patch Clamp System for High-Throughput Ion Channel Screening Ion channels are a viable and under- represented target class in the pharmaceutical...read more

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Molecular Devices®

Reviews

Subramaniam Jayanthi


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Member since 2006

Organization:
National Institute Drug Abuse
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RATING: 3.3

  • 3 out of 5EASE OF USE
  • 3 out of 5AFTER SALES SERVICE
  • 4 out of 5VALUE FOR MONEY




Review date: 19 Dec 2011

IonWorks® Quattro Automated Patch Clamp System

"I find this system easy to use."

Read 4 reviews

Michael Finley


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Member since 2011

Organization:
Merck
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RATING: 4.0

  • 4 out of 5EASE OF USE
  • 4 out of 5AFTER SALES SERVICE
  • 4 out of 5VALUE FOR MONEY




Review date: 13 May 2011

IonWorks® Quattro Automated Patch Clamp System

"The IonWorks Quattro is a very reliable machine with high (384-well format) throughput. Although user intervention is required to test multiple plates and continually provide fresh cells, the device itself is relatively easy to operate. The software is not entirely user-friendly, but it also isn't so complex that a user cannot figure it out within a couple of days/weeks of use."

Jean Marie Chambard


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Member since 2007

Organization:
Sanofi-Aventis
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RATING: 3.6

  • 3 out of 5EASE OF USE
  • 4 out of 5AFTER SALES SERVICE
  • 4 out of 5VALUE FOR MONEY




Review date: 12 Oct 2007

IonWorks® Quattro Automated Patch Clamp System

Quiang Lu


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Member since 2005

Organization:
Wyeth Research
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RATING: 3.6

  • 3 out of 5EASE OF USE
  • 4 out of 5AFTER SALES SERVICE
  • 4 out of 5VALUE FOR MONEY




Review date: 27 Sep 2005

IonWorks® Quattro Automated Patch Clamp System

"Work horse-like."

Description

 

Molecular Devices Introduces IonWorks Quattro Automated Patch Clamp System for High-Throughput Ion Channel Screening Ion channels are a viable and under- represented target class in the pharmaceutical industry. Conventional patch clamping of a single cell at a time, the "gold standard" for studying ion channels, is labor intensive and not amenable to screening large numbers of compounds in early stage drug discovery. As a result, surrogate measures of ion channel activity, such as ligand displacement, ionic flux and membrane potential are used, but these assays cannot maintain a population of ion channels in a particular conformational state due to the lack of voltage control. Recent advances in planar patch clamp technology commenced the era of ion channel screening using a direct electrophysiological assay, and several instruments are commercially available, including the IonWorks ® Barracuda and PatchXpress ® 7000A systems from Molecular Devices. Although these systems offer considerably higher throughput than conventional patch clamping, there is still a pressing need to match the throughput of surrogate assays while simultaneously driving down the per compound assay costs. To achieve such a goal, Molecular Devices developed the IonWorks ® Quattro™ system with Population Patch Clamp™ (PPC) technology.

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