The ionBooster enhances sensitivity and lowers detection limits by increasing ionization efficiency in a wide range of applications. The ionBooster can be used with the latest Bruker amaZon speed, maXis, maXis impact or solariX MS systems, and is quickly and easily installed. For a wide range of compounds, the ionBooster achieves sensitivities that rival those of industry-leading QQQs, while still providing the known benefits of MSn or accurate mass values with TIP™ (True Isotopic Pattern). The ionBooster has simple operating parameters and nitrogen consumption requirements that are similar to those of conventional sources.