The Human Inflammatory Cytokines & Receptors RT² Profiler PCR Array profiles the expression of 84 key genes mediating the inflammatory response. Acute inflammation occurs in response to cell damage due to infection or injury. During this process, cellular and plasma derived factors encourage extravasation, the recruitment of circulating immune cells into the affected tissue. These immune cells in turn up-regulate the expression of inflammatory cytokines that recruit additional immune cells to mount an immune response to any invading organisms and to further promote and eventually resolve the inflammatory response. Chronic inflammation, or expression of these cytokines and receptors at low levels over long periods of time, promotes various pathological conditions including allergies and asthma, cardiovascular system disorders (atherosclerosis), central nervous system disorders (Alzheimer’s disease), fibrosis, and rheumatoid arthritis. This array contains genes involved in mediating immune cascade reactions during inflammation. The chemokines, cytokines, and interleukins involved in the inflammatory response are represented as well as their receptors. Profiling the expression of these inflammatory cytokine and receptor genes helps determine the state of and the mechanisms behind inflammation in your experimental model system. Using real-time PCR, you can easily and reliably analyze expression of a focused panel of genes related to inflammation with this array.
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