The HoneyBee 161 is a flexible platform capable of setting up sitting drop, hanging drop and MicroBatch crystallization reactions as well as sequencing and PCR based assays. Low volume (nL) dispensing of the precipitant solutions is accomplished using market proven synQUADTM technology from Genomic Solutions across 16 channels while protein is added via an additional independently controled synQUADTM channel. The Honeybee 161 provides precise and accurate non-contact dispensing of low volumes and conservation of valuable protein sample. The non-contact synQUADTM technology maintains precision at low volumes with even the most challenging solutions such as detergents and more viscous solutions e.g. 30% PEG.