Looking for robust and validated cell lines transfected with ion channel targets? Aurora Biomed Inc. offers cell lines for purchasing and licensing for some of the most common drug discovery ion channel targets. Our cell line collection includes the hERG and Kv1.3 potassium channels, and the Nav1.5 sodium channel. Each cell line has been optimized by our assay development team to stably express the ion channel of interest, and has been validated using both flux assays and electrophysiology. The window of detection (signal/noise) of these cell lines is appropriate for high-throughput screens. These cell lines, when used with our proprietary Ion Channel Reader and optimized reagens, can help generate robust, sensitive assays for ion channel screening. Drug-induced blockage of the human ether-a-go-go (hERG) potassium channel is associated with prolonged QT, which can predispose individuals to arrhythmias such as Torsades de Pointes. Therefore, early screening of compounds for hERG channel activity is a vital step in the drug-discovery process. Our CHO-hERG cell line was developed and validated as a tool for screening compounds which may lead to QT prolongation. - Stably expresses hERG potassium channels - Validated using electrophysiology and flux assay - Suitable for high-throughput screening (HTS)
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