GQSAR (group based QSAR) is a patent pending methodology developed by VLife that simplifies the conventional QSAR approaches by mitigating interpretation challenges. It studies relation of molecular fragments of interest and the variation in their biological response while considering interactions between fragments through cross term fragment descriptors. With GQSAR, users will obtain site specific clues for designing new molecules and quantitatively predicting their activity. GQSAR thus comes out as efficient and more suitable approach in Ligand based design approach.