The new Bruker Daltonics esquire6000™ robust and sensitive ion trap system provides standard and high-performance MS and MS(n) for liquid chromatography mass spectrometry applications in drug discovery, drug development, academic research and general LC/MS/MS. Bundled with application-specific software packages, this LC-ESI/MS(n) ion trap is a highly productive tool for demanding applications like fast screening of natural products, structural elucidation, quality control, mass-directed auto-purification, LC/NMR/MS/MS, etc. The esquire6000 features an m/z range up to 6,000. The system is at least twice as sensitive as the esquire3000plus which it replaces. This proven and sensitive ion trap is a workhorse for LC/MSn applications. It has extended MSn capabilities.