- Ease of use
- After sales service
- Value for money
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Description
Echo® 500 series liquid handlers enable assay miniaturization with the routine use of higher density, lower well-volume microwell plates. Using truly touchless acoustic droplet ejection (ADE) technology, Echo liquid handlers provide more precise and more accurate results for a wide range of life science applications. ADE uses sound energy to transfer 2.5 nL droplets from Echo-qualified 384- and 1536-well source plates into 96-, 384-, 1536- and 3456-well destination plates. This unique touchless technology eliminates consumable tip costs, washing, and cross-contamination. Unsurpassed volumetric precision (≤ 8% CV) and accuracy (≤ 10% CV) ensure superior results. Independent studies have shown that Echo liquid handlers eliminate false negatives due to sample loss on tip surfaces in low-concentration transfers. With three models to choose from, the Echo® 500 series liquid handlers bring the power of ADE to labs with a wide range of life science applications and needs.
Imagine preparing assay plates for siRNA screening, compound screening with biochemical and cell-based assays, PCR reactions and more all on a single liquid handling platform, with no tips and no cross-contamination. Labcyte has developed new acoustic droplet ejection (ADE) parameters that deliver built-in intelligence to enable users to transfer many different fluid types from a single instrument. All Echo systems come pre-calibrated so that you can switch among different fluid types with just a click of the mouse. No further adjustment is required for you to be productive immediately. These developments combine the latest discoveries in wavelength, power and timing requirements for ADE with real-time fluid measurement at multiple points during a run. The resulting algorithms solve some of the most significant liquid handling challenges with volatile, low-surface tension and/or meniscus-shifting fluids. Volumetric accuracy and precision for all fluids tested so far—including buffers, nucleic acid and protein solutions, surfactants, serum and cell culture media—are comparable to established performance with DMSO.
Applications:
• Compound management
• Compound screening
• siRNA screening
• Biochemical assays
• Cell-based assays
• PCR
• Genotyping
• Gene expression
Application notes and news
- Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo® Liquid Handler
- Automated RT-qPCR Utilizing the Access™ Workstation, the Echo® Liquid Handler, and RealTime Ready™ Reagents
- High Throughput RT-qPCR for Gene Expression Analysis
- Echo® Application Highlight Miniaturized Genotyping Reactions
- Miniaturized Quantitative PCR in 1536-Well Plate Format Using the Echo® Liquid Handler
- Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo® Liquid Handler
- Miniaturized Genotyping Reactions with the Echo® Liquid Handler
- Miniaturised High-Throughput siRNA Workflows and High-Throughput, low volume, siRNA Screening
- Assay Assembly for Miniaturized Quantitative PCR in a 384-well Format Using the Echo® Liquid Handler
- New Real-time Dynamic Monitoring for Echo® Liquid Handlers Enables Expanded Fluid Types and Applications
- A Sound Combination for Superior Miniaturized Assay Preparation
- Automatic Acoustic Liquid Handling with Dynamic Fluid Analysis™
- QIAGEN to Provide siRNA Libraries in Labcyte Acoustically Compatible Microplates
- Labcyte Receives 1st Patent in China for Droplet Ejection Technology and Liquid Transfer
- Labcyte Expands Acoustic Dispensing and Launches Into New Markets
- Labcyte Introduces Powerful New Fluid Capabilities for Echo Liquid Handlers at LabAutomation 2010
Reviews
Corrie Lade Status: See all reviews Member since 2013 Organization: Broad Institute Read more » | RATING: 4.0 
"Intuitive software. Although an expensive instrument it saves money long-term with no consumable costs. Allows for dispensing of much lower volumes that most other dispensers."   |
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| Maria Galou Lameyer Status: See all reviews Member since 2013 Organization: Bristol Myers Squibb Read more » | RATING: 5.0
"The Echo 500 is great. We are processing genotyping analysis by Real Time PCR and carry over is our nightmare. With the Echo 500 no more headaches. No cross contamination. No carry over. Fast and good for the environment . You can dispense a 384 well plate in 4min and no plastic tips waste." |
Sarah Wise Status: See all reviews Member since 2013 Organization: Gilead Read more » | RATING: 4.0
"The ECHO gets 5 stars for ease of use because it works precisely and reliably with a very intuitive software for everything except the serial dilution capabilities--that is still in need of lots of work. Everything else, plate to plate transfer, reformat, etc, is awesome. Service can be spotty. Some technicians are very good, but others to not seem to know what they are talking about leaving the instrument down for days. But all in all, I love it." |
Sharmin Sheikh Status: See all reviews Member since 2013 Organization: Monsanto Read more » | RATING: 5.0
"I have found the instrument to be very refined, error proof, smooth running and easy to use." |
| Rebecca Snell Status: See all reviews Member since 2012 Organization: AstraZeneca Read more » | RATING: 4.3
"Very easy to use, expensive but worth the money. I would recommend them to a colleague." |
| Ekaterina Bobkova Status: See all reviews Member since 2012 Organization: Sanford-Burnham Institute for Medical Research Read more » | RATING: 3.3
"Very useful robust nL dispenser. However, in my experience, the software does malfunction." |
| David Lasky Status: See all reviews Member since 2012 Organization: Life Technologies Read more » | RATING: 4.3
"As novel and innovative as Labcyte's technology is in the Echo, the very high price point limits our ability to interpret it further in our labs. We would love to see lower dead-volume 384-LDV source plates to help conserve compound." |
| Paul Kadwill Status: See all reviews Member since 2011 Organization: GlaxoSmithKline Read more » | RATING: 3.3
"Good system with many positives e.g. it is easy to use. However it can have issues with sensitivity- compounds in DMSO have to be at room temperature to dispense fully." |
| Georgina Green Status: See all reviews Member since 2011 Organization: Glaxosmithkline Read more » | RATING: 5.0
"It is easy to use the equipment and create protocols to suit. This instrument is easily integrated with other automation, however it is not suitable for all plate types (flat bottom source plates only)." |
| James Roberts Status: See all reviews Member since 2011 Organization: Dundee University Read more » | RATING: 4.0
"We use the Labcyte for nl dispensing. It helps us to reduce our compound consumption and when we used it for DRC plate preparation it improved the quality." |
| Ben Sumoreeah Status: See all reviews Member since 2006 Organization: GlaxoSmithKline Read more » | RATING: 3.3
"Excellent volume dispensing tracking. Accurate and consistent equipment." |
| jonathon orme Status: See all reviews Member since 2007 Organization: Astrazeneca Read more » | RATING: 3.6
"In our lab it has improved assay reproducibility significantly removing time consuming pipetting." |
| Larry Ross Status: See all reviews Member since 2011 Organization: Southern Research Institu Read more » | RATING: 4.3
"Very good instrument though when there are problems they can be difficult to solve." |
| Peter Goldenblatt Status: See all reviews Member since 2007 Organization: Merck and Campany Inc. Read more » | RATING: 3.6
"Enables small volume screening." |
| Catherine Quintero Status: See all reviews Member since 2011 Organization: Merck & Co Inc. Read more » | RATING: 3.6
"Easy to program, easy to use, hard to get service." |
| Ron Geurts Status: See all reviews Member since 2011 Organization: MSD Read more » | RATING: 4.3
"Easy to use, non contact dispensing." |
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