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Member since: 2016
Organization: BioBank AS
Superb and powerful QC tool! Combines the best features from nanodrop and picogreen and even adds more info on top!
Application Area: Nucleic acid analysis, post-extraction quality control
"This is a fantastic tool and QC platform for biobanks. We focus on DNA extraction and pre-analysis QC. We don't perform any downstream analysis ourselves but ship normalized DNA to third party laboratories and therefore we need as much QC information as possible. As a high throughput laboratory, our QC must have both a reasonable analysis price and be quick and easy to use on a variety of samples. This full platform combines the best of both nanodrop and picogreen worlds and can be done with as little as 2µl of sample. The system is very powerful and gives a tremendous amount of data. Software is easy to use but you have to play around with it to learn which buttons to use and which to leave alone to be able get the info you need. There are a lot of parameters and variables so the interface may look a bit chaotic at first. Be aware that the system comes with the DropQuant software and you need the cDROP add-on to be able to get the full features. However, it is very well worth it as this expensive add-on gives you a very powerful software. The results are very comparable to picogreen (dsDNA) results. It also looks like the reliability is very good as I have got nothing but good feedback from our third party laboratories. What initially may feel like a little drawback with such a powerful tool as cDROP is that there is no such thing as one universal software protocol that can be used on all samples. If you want to use the complete set of cDROP features the software needs a kit/source specific protocol. Software comes with a lot of pre-installed protocols but your specific combination of source and kit may not be there. Luckily, the protocol developers at Trinean are very helpful so in the end this is no problem or drawback at all. However, nucleic acids isolated with self-established DNA extraction protocols or so called "quick and dirty" extraction methods may not be optimal for cDROP. This will be something that the protocol developing team will help you with. "
Member since: 2016
It is very convenient to perform a measurement for many samples.
Application Area:Quality check of PCR products
"pros: Measure many samples simultaneously We do not have to wipe out after every measurement as we do for NanoDrop cons: Spend more consumables than the NanoDrop Worn out after I perform many measurements because it is too hard to pick up the plate. It is so useful when we perform a measurement for many samples, but it is unfortunate that we hardly measure so many samples. "
The Trinean DropSense96® is a multi-functional platform for quick and precise UV/VIS analysis and dye-free quantification and content QC of micro-volume biosamples.
The DropSense96® platform combines:
- DropSense96® reader: the only high-throughput UV/VIS spectrophotometer for microliter sample volumes currently in the market, analyzing up to 96 samples in less than 5 minutes. The instrument can be used manually or integrated into any robot to ensure fully automated droplet quantification. A software toolbox is available for integration (API) and regulated labs (CFR 21 part11 ready).
- Micro-volume DropPlates: microfluidic design for 2 µl samples loaded and sample preservation up to 2 hours. Sample analysis by micro-cuvettes generating an extensive measurement range from 0.1 up to 200 OD (10 mm conversion). The DropPlate96 is barcoded and has a SBS/ANSI footprint for compatibility with liquid robots.
- Analytical software: DropQuant for classic UV/VIS analysis with A260 or A280 quantification. Add-on cDrop® analytical package can be used for detailed content analysis of impure samples. This spectral content profiling software uses the UV/Vis spectral data by the DropSense96® to extract specific and reliable quantitative information by defining the spectral contribution of the isolate and potential contaminants present. The software packages allow easy experimental design and LIMS compatible reporting.
The Trinean technology is the method of choice for QC and QA of biomolecules, given its sample purity analysis, dynamic measurement range, small sample consumption and operational efficiency.