The Thermo Scientific DNAPac® PA200 is a strong anion-exchange column developed to provide unsurpassed high-resolution analysis and purification of synthetic oligonucleotides. DNAPac PA200 can resolve full length from n–1, n+1, and other failure sequences not possible with other columns. Retention times and selectivity can be controlled by the choice of salt, pH, and solvent. Therefore, the separation can be tailored to the requirements of many different oligonucleotide analysis challenges.
Features: • Achieve n, n-1 resolution for oligonucleotides • Resolve oligonucleotides with secondary structures • Assay phosphorothioate purity • Selectivity control with eluent pH, salt, and solvent • Resolve RNA with aberrant (2’–5’) links from normal ssRNA
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