The new Anatrace Neopentyl Glycol (NG) class detergents are revolutionary new amphiphiles. NG class detergents are a more effective detergent for extracting and solubilizing/stabilizing proteins, and are particularly beneficial in the crystallization process due to some unique properties conferred by a revolutionary new architecture. The amphiphilic molecule consists of a central quaternary carbon with two hydrophilic heads and two lypophilic tails, generating subtle constraints on overall conformational flexibility that allows the molecule to pack densely when forming a micelle. This dense packing increases thermal stability of the detergent/protein complex and most importantly, produces exceptionally low critical micelle concentrations and extreme water solubility. Most significantly, t...Read more
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