SCREEN Cell3iMager by InSphero

The SCREEN Cell³iMager is a robust, high-throughput scanner for the label free profiling of 3D spheroid growth and morphology.

It overcomes the speed and throughput issues of the existing automated microscopes or high content imaging systems featuring high-resolution scanning (200 dpi to 9600 dpi) without compromising scan time. It facilitates analysis of spheroids by fast, parallel scanning in a bright field, allowing determination of single or multiple spheroid count per well as well as diameter, area, pseudo volume, and circularity of individual spheroids without disrupting the spheroid biology.

The companion 3D optimized analysis software allows faster image capture, measurement and data analysis and is compatible with all major 3D cell culture platforms including InSphero’s GravityPLUS™ and GravityTRAP™ plates, providing rapid, robust profiling of key spheroid growth and morphological parameters, including spheroid number, size, shape, and growth kinetics over time.  It can be used to focus selection of therapeutic targets and treatment strategies before costly and tedious testing in animal models. To fit varying budgets and throughput needs, the imager is available in two models: the robotics-compatible single-plate Cell³iMager Neo (cc-3000) or the 4-plate Cell³iMager (cc-5000).

Features:

• High-throughput screening without compromising time (<2min/96 well plate)
• Cost-effective label-free imaging system for kinetic growth profiling of 3D tumor spheroids
• High- correlativity with biochemical assays that monitor viability (e. g., ATP content)
• Intelligent 3D image analysis software with built-in compatibility for all major 3D cell culture platforms