Corning® Supersomes™ Human CYP4F3A + Oxidoreductase +b5, 0.25 nmol by Corning Life Sciences

Corning^® Supersomes™ Human CYP4F3A + Oxidoreductase +b5, 0.25 nmol Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs

CYP4F3A is a non-hepatic P450 enzyme. Its expression is localized to the ER of polymorphonuclear leukocytes (PMNL). CYP4F3A is a major enzyme involved in the ω-oxidation of Leukotriene B₄ (LTB₄) in humans, yielding the biologically less active 20-hydroxylase product. LTB₄ is a potent chemical activator of inflammatory reactions; the turnover of LTB₄ has been used to determine the extent and duration of inflammation. The substrate specificity of CYP4F3A is shown to include several ecosinoids in addition to LTB₄ such as lipoxin A4 and B5, 12-HETE, and 5-HETE. CYP4F3A and CYP4F3B originate from the same pre-curser mRNA. The two isoforms differ by a single exon (exons 3 and 4), originating from a tissue specific alternative splice mechanism.

• Contains Human Oxidoreductase and cytochrome
• Available size: 0.25 nmole P450 in 0.5 mL
• Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.