Prior to the development of Class I and Class II MHC Tetramers, identification of antigen-specific T cells was limited due to lack of sensitivity and specificity in existing technology. Now with unparalleled iTAg MHC Tetramer technology, MHC/peptide binding is utilized to detect antigen and MHC-specific T cells at the single-cell level. The immune response information iTAg MHC Tetramers provides is pivotal in helping make the right decisions during vaccine and drug development as well as clinical trials. MHC Tetramers are complexes of four MHC (Major Histocompatibility Complex) molecules, which are associated with a specific peptide and bound to a fluorochrome. These complexes bind to a distinct set of T cell receptors (TCRs) on a subset of CD8+ T cells. Thus, mixing tetramers with PBLs o...Read more
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