Chromobodies® - Your perfect reagents for cellular research including High-Content Analysis.
Chromobodies are fluorescent nanoprobes suitable for real time analyses of endogenous cellular structures and processes in live cells.
Chromobodies® are a novel species of extremely small intracellular antibodies. They are based on the antigen binding domain (VHH) derived from heavy chain antibodies of camelids genetically fused to a fluorescent protein (e.g.TagGFP or TagRFP from Evrogen).
As opposed to conventional antibodies, these innovative fluorescent nanoprobes are suitable for real time analyses and can visualize endogenous cellular structures and processes in live cells.
All Chromobody® binding domains are carefully selected to not interfere with endogenous protein function and offer the unique possibility to trace native proteins in living cells. Hereby, the understanding of cellular processes in response to external stimuli, which is a major challenge in early drug discovery, compound screening and target validation, can be analyzed thoroughly.
Use our Chromobody technology to explore:
• Cell cycle dynamics (Cell Cycle Chromobody)
• DNA methylation (Dnmt1 Chromobody)
• Nuclear integrity (Lamin Chromobody)
• Actin cytoskleton (Actin Chromobody)
Chromobodies® are available as stable cell lines or as Chromobody® plasmid.