CHO-K1 AequoScreen® Parental Cell Line

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CHO-K1 AequoScreen® Parental Cell Line
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AequoScreen™ Parental cell lines express stably express mitochondrially targeted apoaequorin.GPCRs of your choice can be transiently / stably transfected into these cell lines. Following GPCR stimulation, increases in intracellular calcium enable measurement of the resulting flash luminescence signal. Two vials of cryopreserved cells are shipped per order. Feature/Benefits: Functional, homogenous and generic assay platform for Gs, Gi and Gq coupled GPCRs Fully automatable and miniaturizable to 1536 Enables reduction in reagents and consumable costs High signal to background ratio enabling detection of agonists, antagonists and allosteric modulators Robust assay (Z, CV values, solvent resistance) Reduces the number of false positives from autofluorescent compounds in screeni...Read more

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Description

AequoScreen™ Parental cell lines express stably express mitochondrially targeted apoaequorin.
GPCRs of your choice can be transiently / stably transfected into these cell lines. Following GPCR stimulation, increases in intracellular calcium enable measurement of the resulting flash luminescence signal. Two vials of cryopreserved cells are shipped per order.

Feature/Benefits:

  • Functional, homogenous and generic assay platform for Gs, Gi and Gq coupled GPCRs
  • Fully automatable and miniaturizable to 1536
  • Enables reduction in reagents and consumable costs
  • High signal to background ratio enabling detection of agonists, antagonists and allosteric modulators
  • Robust assay (Z, CV values, solvent resistance)
  • Reduces the number of false positives from autofluorescent compounds in screening libraries
  • Option to work with cells in suspension to increase throughput
  • Amenable for use with calcium coupled ion channels and tyrosine kinase receptors

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CHO-K1 AequoScreen® Parental Cell Line

by PerkinElmer, Inc.

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