The Chirascan Q100 Circular Dichroism (CD) Spectrometer offers comprehensive insight into the Higher Order Structure (HOS) characteristics of complex biomolecules. High-performance CD spectrometry and reproducible robotics combine to produce quality data compatible with the most strict statistical analysis techniques. The outcome: objective, statistically-validated HOS comparisons. Fully integrated for unmanned operation, the Chirascan Q100 saves days of operator time, analyzing 48 buffer-sample pairs in 24 hours whereas a skilled operator can process only up to 14 samples per day on a manual system.
Ready to run
The Chirascan systems are provided with the features and accessories needed for acquisition of superior quality data from ‘day one’.
Molecular Sieve, Activated Charcoal Filter
- Removes common gas impurities
Active Nitrogen Management System
- Software-controlled
- Regulates purge gas consumption
Air-Cooled Xenon Lamp
- Up-time recorded
- Software-controlled
Monochromator
- Dual polarizing prisms maximize light throughput
- Generates horizontally, linearly polarized monochromatic light
Photoelastic Modulator
- Converts horizontally polarized light to circularly polarized light. Alternates between left- and right-handed circular polarized light
Integrated Autosampler
- Precise liquid handling and reproducibility
- Eliminate sample handling errors
- Temperature-controlled storage maintains sample integrity
Temperature-Controlled Sample Chamber
- Continuous temperature ramps (single sample mode)
- Consistent analytical conditions
Water Circulator
- Dissipates heat from sample chamber and sample storage Peltiers
Avalanche Photodiode Detector
- Maximum sensitivity (high signal: noise)
Optics-Based, MultiwaveLength Calibration
- For CD accuracy at every wavelength
Fixed Flow Cells
- Eliminates errors of cuvette handling
- Choice of pathlength to optimize concentration and absorbance
- Recognized by Chirascan Control to choose run/wash/dry protocols
Cuvettes and Holders
- Selected for far- and near-UV CD analysis of biomolecules (single sample mode)
Control and Analysis Software
- Saves time with scheduled start-up/shutdown of lamp and N2 supply
- Easily defined run parameters and store standard protocols
- Ensures O2-free conditions with N2 purge
- Fail-safe lamp switch-off if N2 flow drops
- Recognizes flow cell to choose ideal run/wash/dry protocol
HOS Comparison Software
- Create statistically-validated comparisons
Global Thermodynamic Analysis
- Obtain melting points and enthalpies from multi-wavelength, thermal denaturation experiments (single sample mode)