ChemiSCREEN™ Membrane Preparation Recombinant Human D₂ Dopamine Receptor by Merck

Manufacturer Merck

EMD Millipore's D2 dopamine membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of D2 dopamine receptor interactions with its ligand. The membrane preparations exhibit a Kd of 0.51nM for [125I]-Iodospiperone. With 5.0 ug/well D2 Dopamine Membrane Prep and 0.1nM [125I]-Iodospiperone, a greater than 10-fold signal-to-background ratio... Read more

ChemiSCREEN™ Membrane Preparation Recombinant Human D₂ Dopamine Receptor

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EMD Millipore's D₂ dopamine membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of D₂ dopamine receptor interactions with its ligand. The membrane preparations exhibit a Kd of 0.51nM for [¹²⁵I]-Iodospiperone. With 5.0 ug/well D2 Dopamine Membrane Prep and 0.1nM [¹²⁵I]-Iodospiperone, a greater than 10-fold signal-to-background ratio was obtained.

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