Cardiac Myocytes by PromoCell GmbH

Manufacturer PromoCell GmbH  |  Available Worldwide
Primary Human Cardiac Myocytes   Primary Human Cardiac Myocytes (HCM) are isolated from the ventricles of the adult heart. They are qualified for in vitro research on cardiac diseases and for pharmacological studies. Unlike freshly isolated rod-shaped myocytes, cultured HCM can be used for long-term experiments like investigating the long-term effects of cytokines, mechanical strain, or cell-cell interactions, as they are prepared according to a special protocol. Initially, the HCM act ... Read more


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Human cardiac myocytes
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Primary Human Cardiac Myocytes

 

Primary Human Cardiac Myocytes (HCM) are isolated from the ventricles of the adult heart. They are qualified for in vitro research on cardiac diseases and for pharmacological studies. Unlike freshly isolated rod-shaped myocytes, cultured HCM can be used for long-term experiments like investigating the long-term effects of cytokines, mechanical strain, or cell-cell interactions, as they are prepared according to a special protocol.

Initially, the HCM act more like progenitor cells in that they are not yet fully differentiated. They express the markers of early stage differentiation such as GATA-4 and sarcomeric alpha-actin and have a high capacity for proliferation. When they are grown to confluency and cultivated for an extended period of time, the differentiation process begins. Markers of late differentiation (e.g. sarcomeric alpha-actinin, slow muscle myosin) are increased and the cells begin to form myotube-like structures.


Key Advantages:

  • Various donor profiles available
  • Cryopreserved at P2
  • Guaranteed growth performance for 15 population doublings
  • Tested for sarcomeric alpha-actinin and slow muscle myosin
  • PhD-qualified technical support