BL21-CodonPlus Expression Competent Cells



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BL21-CodonPlus strains are engineered to contain extra copies of genes that encode the tRNAs that most frequently limit translation of heterologous proteins in E. coli.


  • Dramatically improves expression when codon bias is a problem
  • RIL strain for AT-rich genomes and RP strain for GC-rich genomes
  • For proteins from all organisms, not just mammalian
  • Overcomes codon bias problems
  • Expresses all rare E. coli codons
  • Ideal for difficult protein expression