Purified cartilage proteoglycans bind specifically to hyaluronate to form high-MW aggregates in which many proteoglycans are bound to each hyaluronate chain. The proteoglycans bind by a specific site at one end of the protein backbone that is largely devoid of glycosaminoglycan chain (HA-binding region) and has a high affinity for a decasaccharide unit of hyaluronate. The link protein is an integral part of the aggregate structure and has been proposed to form additional bonds, by bridging the proteoglycan molecule and the hyaluronate chain, thereby increasing the strength of binding and giving a more stable aggregate structure(ternary complex). Versican G1 domain bind specifically to hyaluronan and doesn’t bind
to other glycosaminoglycan,DNA. Versican G1 domain can use probe for hyaluronan detection.
Manufacturer AMSBIO | Available Worldwide
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