Status:
ReviewerMember since: 2020
Organization: Texas State University
Consistent sonication of DNA.
Application Area: Sheering plasmid and genomic DNA
"I used this product to sheer genomic DNA for NGS. I am very impressed by the reproducibility of results between samples and across experiments when conditions are maintained. I would recommend this product."
Status:
ReviewerMember since: 2019
Organization: BioLegend Inc
Reproducible results, easy to use and maintain.
Application Area:Sample preparation
"I used the Bioruptor Pico to prepare sonicated chromatin samples for ChIP assay. I have also used to sonicated DNA for MEDIP and MEDIP-seq. In addition, I use the Bioruptor Pico to sonicate protein lysates for WB and IP."
Status:
ReviewerMember since: 2019
Organization: University of Michigan
Amazing!
Application Area:ChIP
"Diagenode is a great company. We recently started using the Biorupter Pico in the lab and it's the best machine - so consistent and so user friendly. It's my lab child. I use the ChIP kits as well, and it's wonderful. All controls work, robust and really reproducible results."
Status:
ReviewerMember since: 2015
Organization: State University of New York At Buffalo
Highly recommended biorupter.
Application Area:Chromatin immunoprecipitation
"The setup and instruction manual are easy to follow. With a 30s on 30s off for ten cycles I can obtain excellent shearing of my chromatin into 200bp fragments."
Status:
ReviewerMember since: 2018
Organization: UCD AMC
Stopped working within 6 Mo, horrible customer service.
Application Area:Sonication of crosslink cell lysate
"Poor customer service, make you jump though many hoops to prove their machine's are not working and even then wont believe their customers. The pico performance was never as good as they claimed and dropped of to nothing with in 6 months."
Status:
Expert ReviewerMember since: 2010
Organization: City of Hope National Medical Center and Beckman Research Institute Department of Cancer Genetics and Epigenetics 1500 E Duar
Good equipment and cannot get good results without it.
Application Area:Chip assay
"Easy to use. Consistently getting high quality results."
Status:
ReviewerMember since: 2015
Organization: City of Hope
Excellent equipment and cannot get good results without it.
Application Area:Chip on Chip assays
"Easy to use. Able to obtain good quality samples with high efficiency. Highly recommend to other users"
Status:
ReviewerMember since: 2016
Organization: University of Rochester
Best sonicator I've ever used.
Application Area:Digest DNA for Chromatin Immunoprecipitation
"Once setup the unit was easy to use and very reproducible. Once we got past the learning curve of setting up, the unit was the easiest I've ever used."
Status:
ReviewerMember since: 2016
Organization: University of Arizona
Consistent, reproducible results, even with a low number of cycles.
Application Area:Sonicate DNA for library sequencing preparation
"The Bioruptor Pico is a very well-manufactured piece of equipment and has so far worked flawlessly for sonicating DNA for library sequencing. It was very easy to un-package, setup, and run, and maintenance is also quite easy as long as you have a good source of lots of distilled water that is not de-ionized. Lastly, it is impressive that comparable results can be achieved with a lower number cycles than on Pico's larger sibling."
Status:
ReviewerMember since: 2016
Organization: Beckman Research Institute of the City of Hope
great results
Application Area:ChIP-seq in tissues and cell lines
"It is easy to use and saves more time while shearing DNA."
Status:
ReviewerMember since: 2016
Organization: University of Pittsburgh
Very happy!
Application Area:Chromatin Immunoprecipitation; shearing of DNA
"We had this machine for two months. Thus far, we are pleased with its performance in terms of user-friendliness and result reproducibility. It is too early to say whether it will deliver the same degree of reproducibility in a year or two, which has been an issue with the previous Bioruptor model."
Status:
ReviewerMember since: 2016
Organization: HHMI at Yale
Time saver! Reproducible results
Application Area:chromatin IP
"the Pico is an instrument we use daily in the lab. The results are very consistent"
Status:
ReviewerMember since: 2013
Organization: The University Of Texas M.D. Anderson Cancer Center
Application Area:Fragmentation of gDNA, cDNA and ChIP DNA for Illumina based NGS
"Bioruptor Pico is a good budget product for mid-throughput samples."
Status:
ReviewerMember since: 2015
Organization: Indiana University
Application Area:Shearing of DNA and chromatin and protein extraction
"The Bioruptor Pico is an easy-to-use, reliable instrument. It reproducibly shears DNA and chromatin from cultured cells and mouse tissue. Optimization of shearing conditions can be done quickly. The Bioruptor Pico has been indispensable for shearing the small volumes required for DNA and chromatin from mouse tissue and tumors."
Status:
ReviewerMember since: 2015
Organization: University of Chicago
Application Area:DNA shearing for MeDIP and chromatin shearing for ChIP.
"Diagenode's Bioruptor® ultrasonicator devices are indeed the "Most cited ultrasonicator" and the most popular in the field of Epigenetics as well as many other fields of biomedical research. The shearing of chromatin by sonication is a critical step for the success of gene target (ChIP) or large genome Next-Generation Sequencing technology (ChIP-Seq) for analysis the protein-DNA interactions in vivo. With my extensive experience with Diagenode's Bioruptor I found it the most easy to be used, importantly very reproducible from one experiment to another, with the best quality of results. I highly recommend to my colleagues the Diagenode's Bioruptors as well as their large number of other product that I have experience: epigenetic products, antibodies. Explanation of rating: 1. Ease of Use: simple, minimum time the device to be set up for sonication. 2. After Sales Care: Diagenode has excellent customer service and technical survive support. 3. Value for Money: In my experience the devices are reliable and could be use for many years without and change in the quality of results. "
Status:
Advanced ReviewerMember since: 2013
Organization: German Cancer Research Center
Application Area:Epigenetics
"This state-of-the-art equipment makes sonication so smoothly. It is very easy to handle and the results are highly reproducible. It is a must-have instrument for people working with chromatin shearing."
The Bioruptor® Pico is the new next-generation all-in-one shearing device, highly optimized for DNA shearing for next-generation sequencing, chromatin shearing for ChIP-seq applications, RNA shearing, protein extraction, and cell/tissue lysis.
The Pico is the shearing device of choice for sequencing applications, providing optimal yields, lengths, and consistency and excels in shearing different fragment size ranges, which are frequently required for downstream applications (e.g. bridge amplification) for sequencing. Moreover, the Pico provides flexibility in other applications saving the need to buy additional equipment. Unlike competing systems, the Pico has high throughput capabilities and can process up to 12 samples at once.
The only ultrasonicator you’ll ever need, optimized for: