The heart of SRU’s BIND® technology is the novel optical properties of the BIND® Biosensors. Each well of a BIND Biosensor incorporates a proprietary optical grating which reflects a narrow range of wavelengths (Peak Wavelength Value or PWV) upon illumination with broadband light. The PWV shifts in response to changes in mass or cellular interactions in proximity of the biosensor surface. SRU’s microplate-based BIND Biosensors are available in 96-, 384-, 384lv- and 1536-well formats with a variety of surface coatings to accommodate a breadth of throughput and application needs. All biosensors are biologically inert and highly resistant to organic solvents including DMSO. Biosensors are compatible with automated liquid handling and conform to SBS standards.
Bare TiO2 biosensors are compatible with both cellular and biochemical applications. They allow for custom coating with any molecule of interest, such as proteins, peptides, antibodies, extracellular matrix proteins or small molecules. BIND Biosensors are also available with pre-coated surfaces for optimized assay performance including streptavidin, aldehyde and extracellular matrix proteins.
Biosensors coated with various densities of pre-activated aldehyde (GA1 and GA3 biosensors) allow for stable immobilization of proteins, peptides and small molecules via primary amine groups. Streptavidin-coated biosensors (SA biosensors) allow immobilization of biotinylated assay components. This group of biosensors as well as bare TiO2 plates, are commonly used in direct and indirect biochemical binding assays.
Additionally, biosensors are available coated with a proprietary mixture of extracellular matrix proteins which promote the association of cells with the biosensor and provide a more physiological environment for cellular assay.