The Multiclamp™ 700B Microelectrode Amplifier combines leading edge electronics design and a wealth of features and functions with an intuitive user interface that simplifies the creation of complex protocols. The applications for this amplifier comprise a wide variety of intracellular or extracellular recordings in electrophysiology, including: Patch clamp (whole-cell, macro-patch, or excised patch) High-speed current clamp (sharp-electrode or field potentials) Voltammetry/amperometry Ion-selective measurements Bilayer recordings With two independent primary headstages and an additional two auxiliary headstages, the Multiclamp 700B Microelectrode Amplifier houses the solution for almost any conceivable electrophysiology recording in one slim, convenient package. Instead of front panel knobs and switches, the MultiClamp 700B Amplifier is controlled by Multiclamp 700B Commander software, a program that runs on a host computer (PC and Macintosh; see Requirements below) and communicates with the amplifier via a USB interface. The intuitive user interface of MultiClamp Commander gives the operator full control of all amplifier functions, while the Quick Select feature enables easy access to saved configurations that apply to particular recording configurations. The optional, user-configurable SoftPanel lets you operate the most commonly used controls using traditional knobs and buttons.