Collagen-induced arthritis (CIA) in mice is widely used as an experimental model for rheumatoid arthritis (RA) in humans. CIA is mediated by autoantibodies, which bind to a particular region of type II collagen, such as CB11 (CNBR-digested fragment of type II collagen) (Terato et al, 1985). Antibody-mediated CIA can be induced by i.v. injection of a combination of four different monoclonal antibodies generated by the ArthroMAB mouse B-hybridoma cell lines. T In the mouse CIA model, the antibody response that is correlated with arthritis is mainly associated with binding to the epitopes of C11b, J1 and U1. This cocktail of 4 purified mouse monoclonal antibodies bind to the well-defined epitopes C11b, J1, D3 and U1, which are spread over the entire CII (CB8, CB10 and CB11 fragments), possi...Read more
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