ArthroMAB™ initiates arthritis via immune complex formation on the surface of cartilage in joints.
ArthroMAB™ is a cocktail of four monoclonal antibodies directed against Collagen. It rapidly induces robust arthritis in all four paws of a variety of mouse strains (e.g., Balb/C–CIA resistant, DBA/1, B10.RIII). Compared to the traditional collagen induced arthritis (CIA) model, the ArthroMAB™ kit (which includes antibody cocktail and bacterial lipopolysaccharide (LPS), induces severe arthritis in mice within days instead of weeks and allows researchers to test far fewer animals since the incidence of arthritis is nearly 100%. Furthermore, synchronized disease onset between mice reduces treatment schedules and simplifies assessment studies, when compared to other arthritis models.