Archimedes is a new, highly innovative instrument which uses the technique of resonant mass measurement to detect and accurately count particles in the size range 50nm - 5µm, and reliably measure their buoyant mass, dry mass and size.
Archimedes is uniquely positioned to quantitatively measure protein aggregates within and beyond the range of 100nm - 1µm, highlighted as a particular concern for immunogenicity and product safety.
Central to Archimedes is a MEMS (Micro Electro-Mechanical Systems) technology sensor, allowing the highly sensitive, reliable and reproducible measurement of aggregates, one by one. Archimedes is also capable of providing information on sample concentration, viscosity, polydispersity, density and volume, and distinguishing between negatively buoyant proteinaceous particles and positively buoyant contaminating silicone oil droplets.
Archimedes Particle Metrology System Features & Benefits:
Ideally positioned for biopharmaceutical manufacturers and developers.
Unique and accurate particle counting capability in the size range 50nm - 5µm.
Exquisite sensitivity: measurement of particle mass to 350ag.
Highly accurate particle size measurement from 50nm to 5µm.
Excellent size resolution, <20nm at 1µm diameter.
Low sample consumption: only 100µL.
Differentiation between negatively buoyant and positively buoyant particles.
Capable of measuring high concentration samples (to 109 particles/mL) and high viscosity samples (to 100cP).