The industry-standard API 4000TM LC/MS/MS System brings high-performance quantitation and identification to every phase of the pharmaceutical development process, from discovery to clinical research trials.
Features of the API 4000TM LC/MS/MS System:
Proven Curtain GasTM interface technology, combined with improved gas dynamics, reduces maintenance and increases uptime.
Enhanced high flow-rate performance, reduced ionization suppression, self-cleaning probe design, and reliable interface ... Read more
API 4000™ LC/MS/MS System
Average Rating: 4.2
25 Scientists have reviewed this product
Status:
Reviewer
Member since: 2016
Organization: Nepenthe Laboratory Services, LLC
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- Ease of use
- After sales service
- Value for money
The Sciex API 4000 is a workhorse!
Rating: 4.0
Application Area: Toxicology testing
"Sciex's excellent Turbo Ion Source is great at keeping the internals as clean as possible. We experience much less fouling with this assembly than we experience with "equivalent" technologies from other companies. Cleaning is relatively simple, and service visits are performed regularly by friendly technicians who know their stuff. Service is expensive, but necessary when you're running a service business like a clinical reference lab. It's too bad they stopped manufacturing these! The API 4500 is a nice instrument, but slightly more issue-prone than the 4000. The fact that they use the same software and source is a definite plus though."
Review date: 11 Jan 2017 | API 4000™ LC/MS/MS System
Status:
Advanced Reviewer Member since: 2015
Organization: GRU
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- Ease of use
- After sales service
- Value for money
Rating: 5.0
Review date: 07 Jul 2015 | API 4000™ LC/MS/MS System
Application Area:Biomarker discovery
"This instrument allows very deep detailed searches for specific transitions with good sensitivity. Well made and easy to use. Interfaces well with third party add-ons."
Review date: 07 Jul 2015 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: Dokuz Eylul University
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 23 Apr 2014 | API 4000™ LC/MS/MS System
Application Area:Clinical Diagnostic, Drug Discovery And Development, Forensic Toxicology, Environmental Tests
"Mass spectrometry has both qualitative and quantitative uses. In our study we used mass spectrometry as it is suitable for use in all areas. Although the high initial purchase cost, it allows for multi-parameter measurements and has decreased the cost per parameter. Targeted with the high accuracy and specificity allows for a quantization. Software and system-dependent parameters is difficult compared to other devices. However, it will be very difficult to learn. With this device we have performed quantitative analysis of methylmalonic acid as a biomarker of vitamin B12 deficiency, damaged DNA nucleosides as a biomarkers of DNA damage and isoprostane levels as a biomarker of lipid peroxidation."
Review date: 23 Apr 2014 | API 4000™ LC/MS/MS System
Status:
Expert Reviewer Member since: 2013
Organization: JRFAmerica
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- Ease of use
- After sales service
- Value for money
Rating: 4.0
Review date: 21 Nov 2013 | API 4000™ LC/MS/MS System
Application Area:Residue Chemistry
"It is a very reliable instrument with good sensitivity, reproducibility and consistency. It does require cleaning and keep up. "
Review date: 21 Nov 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: TÜBİTAK MRC
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- Ease of use
- After sales service
- Value for money
Rating: 4.7
Review date: 12 Aug 2013 | API 4000™ LC/MS/MS System
Application Area:thyreostats, triphenylmethane, dyes, pesticides, phospholipids, grayanotoxins
"I gave 4 stars for ease of use because of some difficulties with overlay and hard processing while undertaking multi-residue pesticide analysis. But of course I would recommend this system to my colleagues. I love AB SCIEX. Their system is very qualified if a little bit expensive. "
Review date: 12 Aug 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: University of Vienna
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- Ease of use
- After sales service
- Value for money
Rating: 3.3
Review date: 08 Aug 2013 | API 4000™ LC/MS/MS System
Application Area:Lipidomics
"The product is very easy to use after getting used to the analyst software. The software is not really user friendly."
Review date: 08 Aug 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2007
Organization: Gedeon Richter Ltd.
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 07 Aug 2013 | API 4000™ LC/MS/MS System
"I like it very much, because API 3000 and 4000 have a good sensitivity and it is easy to use. The Analyst software is very good."
Review date: 07 Aug 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: laboratoire de Fougeres
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- Ease of use
- After sales service
- Value for money
Rating: 4.7
Review date: 07 Aug 2013 | API 4000™ LC/MS/MS System
Application Area:detection and confirmation of antibiotics
"This instrument is very robust. It has a great sensitivity and is easy to use. It is suitable for confirmation of drugs in biological matrices and gives good results in term of accuracy, precision and sensitivity."
Review date: 07 Aug 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: Teva
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- Ease of use
- After sales service
- Value for money
Rating: 3.0
Review date: 26 Jun 2013 | API 4000™ LC/MS/MS System
Application Area:Pharmaceutical
"4000 trap is a good advanced, powerful system but the software is not nice. I would appreciate a more user-friendly software for scientists to use in the fields."
Review date: 26 Jun 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: Critical Path Services, LLC
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- Ease of use
- After sales service
- Value for money
Rating: 3.7
Review date: 03 Jun 2013 | API 4000™ LC/MS/MS System
Application Area:trace analysis
"Excellent sensitivity but the software needs to be updated to be more visually appealing and easier to use."
Review date: 03 Jun 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: University of Pennsylvania
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- Ease of use
- After sales service
- Value for money
Rating: 4.0
Review date: 29 May 2013 | API 4000™ LC/MS/MS System
Application Area:analytical toxicology
"Provides good sensitivity, it’s reliable, accurate and the software is easy to use. Drawback is the high cost to maintain."
Review date: 29 May 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: University of Connecticut
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 29 May 2013 | API 4000™ LC/MS/MS System
Application Area:research
"This instrument is easy to use and fast for MRM detection of complex bio samples. It can detect a few femtomole of analyte with nanoLC at the front, in a very satisfactory way."
Review date: 29 May 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: Missouri University of Science and Technology
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 28 May 2013 | API 4000™ LC/MS/MS System
Application Area:biomedical
"This instrument is easy to use and for most time can produce good quality data. Also it is easy to learn. I am a new user for this instrument and it only took me less than two months to learn how to use it. Although sometimes it may cause some problems but it doesn’t take a long time to fix that. Overall, it is an awesome instrument to help us to move on my project and give me very good data to present. I will definitely recommend this to my colleagues. What I want to know more about this instrument is that how to actually clean the MS part."
Review date: 28 May 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: Food and Drug Administration
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- Ease of use
- After sales service
- Value for money
Rating: 5.0
Review date: 23 May 2013 | API 4000™ LC/MS/MS System
Application Area:pharmacology, pharmacokinetics
"It is good technology for quantitative analysis. In the past, I supervised people using it in the lab and people were generally happy with the performance."
Review date: 23 May 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2013
Organization: Missouri University of Science and Technology
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- Ease of use
- After sales service
- Value for money
Rating: 3.3
Review date: 22 May 2013 | API 4000™ LC/MS/MS System
Application Area:Environmental analysis
"This instrument is very good for trace analysis of organic compounds. The sensitivity is pretty good and easy to operate. We used it to analyze PPCP (pharmaceuticals and personal care products) level in drinking water system. We also used it for the detection of the emergency contaminants like DBPs in Missouri drinking water system. Pros: high sensitivity, reliable quantification. Cons: configuration with some LC systems is very complex."
Review date: 22 May 2013 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2007
Organization: C.F.S.L.
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- Ease of use
- After sales service
- Value for money
Rating: 5.0
Review date: 18 Jul 2012 | API 4000™ LC/MS/MS System
"The best ion source and the best triple quad ion optics."
Review date: 18 Jul 2012 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: University Of Illinois
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- Ease of use
- After sales service
- Value for money
Rating: 3.7
Review date: 23 Feb 2012 | API 4000™ LC/MS/MS System
Application Area:Drug metabolism study
"Very robust, easy to use and lots of relative software."
Review date: 23 Feb 2012 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: Kirchow Institut
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 02 Nov 2011 | API 4000™ LC/MS/MS System
"A robust, high quality system with good, flexible software."
Review date: 02 Nov 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: Kirchow Institut
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 02 Nov 2011 | API 4000™ LC/MS/MS System
"Robust and easy to clean. Good for blood and plant sample analysis."
Review date: 02 Nov 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2007
Organization: C.F.S.L.
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- Ease of use
- After sales service
- Value for money
Rating: 5.0
Review date: 05 Oct 2011 | API 4000™ LC/MS/MS System
"It the best work horse for food testing laboratories, as well as bio equivalence and bio availability studies."
Review date: 05 Oct 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: Philip Morris Research Laboratories
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- Ease of use
- After sales service
- Value for money
Rating: 2.3
Review date: 22 Aug 2011 | API 4000™ LC/MS/MS System
"There are problems with the software, our instrument often needs rebooting. We have also experienced sensitivity losses."
Review date: 22 Aug 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: University Of Illinois
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- Ease of use
- After sales service
- Value for money
Rating: 4.7
Review date: 20 Jun 2011 | API 4000™ LC/MS/MS System
"A great instrument. The most sensitive instrument ever used."
Review date: 20 Jun 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2011
Organization: pfizer
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 13 Jun 2011 | API 4000™ LC/MS/MS System
"user friendly, very robust."
Review date: 13 Jun 2011 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2006
Organization: Covance
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- Ease of use
- After sales service
- Value for money
Rating: 4.7
Review date: 16 Apr 2009 | API 4000™ LC/MS/MS System
Review date: 16 Apr 2009 | API 4000™ LC/MS/MS System
Status:
Reviewer Member since: 2009
Organization: WADSWORTH LAB, NYSDOH
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- Ease of use
- After sales service
- Value for money
Rating: 4.3
Review date: 15 Apr 2009 | API 4000™ LC/MS/MS System
"I have owned 2 for 4-years and I'm planning to buy another (or follow on)."
Review date: 15 Apr 2009 | API 4000™ LC/MS/MS System
The industry-standard API 4000TM LC/MS/MS System brings high-performance quantitation and identification to every phase of the pharmaceutical development process, from discovery to clinical research trials.
Features of the API 4000TM LC/MS/MS System:
- Proven Curtain GasTM interface technology, combined with improved gas dynamics, reduces maintenance and increases uptime.
- Enhanced high flow-rate performance, reduced ionization suppression, self-cleaning probe design, and reliable interface all combine for accelerated productivity and high throughput.
- Windows NT® platform-based Analyst® software facilitates GLP compliance, including 21 CFR Part 11.
Product Overview
