Status:
ReviewerMember since: 2016
Organization: Nepenthe Laboratory Services, LLC
The Sciex API 4000 is a workhorse!
Application Area: Toxicology testing
"Sciex's excellent Turbo Ion Source is great at keeping the internals as clean as possible. We experience much less fouling with this assembly than we experience with "equivalent" technologies from other companies. Cleaning is relatively simple, and service visits are performed regularly by friendly technicians who know their stuff. Service is expensive, but necessary when you're running a service business like a clinical reference lab. It's too bad they stopped manufacturing these! The API 4500 is a nice instrument, but slightly more issue-prone than the 4000. The fact that they use the same software and source is a definite plus though."
Status:
Advanced ReviewerMember since: 2015
Organization: GRU
Application Area:Biomarker discovery
"This instrument allows very deep detailed searches for specific transitions with good sensitivity. Well made and easy to use. Interfaces well with third party add-ons."
Status:
ReviewerMember since: 2011
Organization: Dokuz Eylul University
Application Area:Clinical Diagnostic, Drug Discovery And Development, Forensic Toxicology, Environmental Tests
"Mass spectrometry has both qualitative and quantitative uses. In our study we used mass spectrometry as it is suitable for use in all areas. Although the high initial purchase cost, it allows for multi-parameter measurements and has decreased the cost per parameter. Targeted with the high accuracy and specificity allows for a quantization. Software and system-dependent parameters is difficult compared to other devices. However, it will be very difficult to learn. With this device we have performed quantitative analysis of methylmalonic acid as a biomarker of vitamin B12 deficiency, damaged DNA nucleosides as a biomarkers of DNA damage and isoprostane levels as a biomarker of lipid peroxidation."
Status:
Expert ReviewerMember since: 2013
Organization: JRFAmerica
Application Area:Residue Chemistry
"It is a very reliable instrument with good sensitivity, reproducibility and consistency. It does require cleaning and keep up. "
Status:
ReviewerMember since: 2013
Organization: TÜBİTAK MRC
Application Area:thyreostats, triphenylmethane, dyes, pesticides, phospholipids, grayanotoxins
"I gave 4 stars for ease of use because of some difficulties with overlay and hard processing while undertaking multi-residue pesticide analysis. But of course I would recommend this system to my colleagues. I love AB SCIEX. Their system is very qualified if a little bit expensive. "
Status:
ReviewerMember since: 2013
Organization: University of Vienna
Application Area:Lipidomics
"The product is very easy to use after getting used to the analyst software. The software is not really user friendly."
Status:
ReviewerMember since: 2007
Organization: Gedeon Richter Ltd.
"I like it very much, because API 3000 and 4000 have a good sensitivity and it is easy to use. The Analyst software is very good."
Status:
ReviewerMember since: 2013
Organization: laboratoire de Fougeres
Application Area:detection and confirmation of antibiotics
"This instrument is very robust. It has a great sensitivity and is easy to use. It is suitable for confirmation of drugs in biological matrices and gives good results in term of accuracy, precision and sensitivity."
Status:
ReviewerMember since: 2013
Organization: Teva
Application Area:Pharmaceutical
"4000 trap is a good advanced, powerful system but the software is not nice. I would appreciate a more user-friendly software for scientists to use in the fields."
Status:
ReviewerMember since: 2013
Organization: Critical Path Services, LLC
Application Area:trace analysis
"Excellent sensitivity but the software needs to be updated to be more visually appealing and easier to use."
Status:
ReviewerMember since: 2013
Organization: University of Pennsylvania
Application Area:analytical toxicology
"Provides good sensitivity, it’s reliable, accurate and the software is easy to use. Drawback is the high cost to maintain."
Status:
ReviewerMember since: 2013
Organization: University of Connecticut
Application Area:research
"This instrument is easy to use and fast for MRM detection of complex bio samples. It can detect a few femtomole of analyte with nanoLC at the front, in a very satisfactory way."
Status:
ReviewerMember since: 2013
Organization: Missouri University of Science and Technology
Application Area:biomedical
"This instrument is easy to use and for most time can produce good quality data. Also it is easy to learn. I am a new user for this instrument and it only took me less than two months to learn how to use it. Although sometimes it may cause some problems but it doesn’t take a long time to fix that. Overall, it is an awesome instrument to help us to move on my project and give me very good data to present. I will definitely recommend this to my colleagues. What I want to know more about this instrument is that how to actually clean the MS part."
Status:
ReviewerMember since: 2013
Organization: Food and Drug Administration
Application Area:pharmacology, pharmacokinetics
"It is good technology for quantitative analysis. In the past, I supervised people using it in the lab and people were generally happy with the performance."
Status:
ReviewerMember since: 2013
Organization: Missouri University of Science and Technology
Application Area:Environmental analysis
"This instrument is very good for trace analysis of organic compounds. The sensitivity is pretty good and easy to operate. We used it to analyze PPCP (pharmaceuticals and personal care products) level in drinking water system. We also used it for the detection of the emergency contaminants like DBPs in Missouri drinking water system. Pros: high sensitivity, reliable quantification. Cons: configuration with some LC systems is very complex."
Status:
ReviewerMember since: 2011
Organization: Philip Morris Research Laboratories
"There are problems with the software, our instrument often needs rebooting. We have also experienced sensitivity losses."
Features of the API 4000TM LC/MS/MS System: