Alexa FluorTM 647 Mouse anti-Ms, Hu BD™ Phosflow Stat1 (pY701) by BD Biosciences
Manufacturer BD Biosciences
The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription (reviewed in 1). Stat1 (Stat91/84) and Stat2 (Stat113) were the first identified members of the Stat protein family. The 91 and 84 kDa proteins are the result of alternate splicing of the Stat1 gene, and Stat91 has 38 additional C-terminal amino acids. Both Stat1 and Stat2 polypeptides contain both SH2 and SH3 domains, and are components of the ISGF3 (interferon-stimulated gene factor 3) complex.... Read more
Alexa FluorTM 647 Mouse anti-Ms, Hu BD™ Phosflow Stat1 (pY701)
The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription (reviewed in 1). Stat1 (Stat91/84) and Stat2 (Stat113) were the first identified members of the Stat protein family. The 91 and 84 kDa proteins are the result of alternate splicing of the Stat1 gene, and Stat91 has 38 additional C-terminal amino acids. Both Stat1 and Stat2 polypeptides contain both SH2 and SH3 domains, and are components of the ISGF3 (interferon-stimulated gene factor 3) complex.
ISGF3 is the primary transcription activator induced by the binding of interferon to a specific cell surface receptor. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Tyr-701 and the complex is translocated to the
nucleus. This results in the formation of an active complex that includes the DNA binding p48 subunit. This complex is responsible for modulating the transcription of the interferonstimulated genes (ISGs). Thus, phosphorylation of Tyr-701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex.
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Alexa FluorTM 647 Mouse anti-Ms, Hu BD™ Phosflow Stat1 (pY701)
Manufacturer BD Biosciences
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