Status:
Reviewer
Member since: 2019
Organization: University Of Southampton
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- Ease of use
- After sales service
- Value for money
Perfect for any lab!
Application Area: Pharmaceutical polymers
"The software is really straightforward and easy to use, however it could be complicated for new users. Waters have provided amazing care with emails and engineers coming when anything happens to the instrument. 100% worth the value."
Review date: 02 Feb 2021 | ACQUITY UPC² System
Status:
Reviewer Member since: 2019
Organization: Chromicent
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- Ease of use
- After sales service
- Value for money
Waters Acquity UPC² adds a complementary strategy to the toolbox of scientists.
Application Area:Analyse Nitrosamine in valsartan, sartane and other API's
"Through our study, a large class of different nitrosamines in the ppb range and sartan-related impurities could be determined simultaneously in a single analysis using WATERS Acquity UPC² in combination with Xevo TQ-S mass detector. By using a systematic Quality-by-Design approach, a highly sensitive method was developed, which can detect nitrosamines in the picogram to femtogram range on column. The sensitivity of the developed method is more unrivalled in comparison to published LC- and GC–MS/MS methods."
Review date: 18 Nov 2019 | ACQUITY UPC² System
Status:
Reviewer Member since: 2019
Organization: University Of Utah
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- Ease of use
- After sales service
- Value for money
With an attached ESI-MS, I don't need to derivatize my products to add a chromaphore.
Application Area:Separation of enantiomers
"This product is the best in the business for supercritical fluid chromatography. I highly recommend it, but the software does have bugs that I deal with."
Review date: 22 Jul 2019 | ACQUITY UPC² System
Status:
Reviewer Member since: 2018
Organization: Graybug Vision Inc.
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- Ease of use
- After sales service
- Value for money
Excellent instrument
Application Area:Pharmaceutical drug product analysis
"I am pleased with the results as it delivered as promised. Good precision, easy sequence creation with ability to precondition the column before run and to wash after run. Delivers adequate pressure for faster runs."
Review date: 27 Sep 2018 | ACQUITY UPC² System
Status:
Reviewer Member since: 2018
Organization: Université d'Orléans
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- Ease of use
- After sales service
- Value for money
Great system, a reference for supercritical fluid chromatography
Application Area:pharmaceutical compounds
"The system allows for high quality results. It is rather expensive, and expensive to maintain but is highly reliable."
Review date: 24 Jul 2018 | ACQUITY UPC² System
Status:
Reviewer Member since: 2015
Organization: Reach Separations
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- Ease of use
- After sales service
- Value for money
If we removed this instrument our company would be taking a very large backward step.
Application Area:Analysis of Chiral and Achiral Molecules by SFC
"The Waters UPC2 produces higher quality data than any other analytical SFC on the market. Its ability to not only deliver precision down to 0.05% of the opposite isomer for chiral analysis, but the same level in achiral SFC is exceptional. It is very robust, we use our equipment 22 hours a day 5 days a week and have experienced 3 days out of action in the last 18 months. It is clear from the current market trends that the UPC2 is becoming the front line instrument for all types of areas which is only a positive for the pharma, agro and fine chemical sectors. This instrument is only a positive for the world of science."
Review date: 29 Jul 2016 | ACQUITY UPC² System
Status:
Reviewer Member since: 2014
Organization: QC
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- Ease of use
- After sales service
- Value for money
"Easy to use. Cost effective and environmentally friendly. It saves time and money."
Review date: 30 Jun 2016 | ACQUITY UPC² System
Status:
Reviewer Member since: 2015
Organization: UNICAMP
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- Ease of use
- After sales service
- Value for money
I can´t recommend this pump since it isn´t working properly.
Application Area:Analytical chemistry
"I´m facing several problems with this pump. Check-valves are not working adequately and I´m not getting a constant flow, which is necessary to obtain good chromatographic performance (SFC)."
Review date: 30 Jun 2016 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: University of Amsterdam
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- Ease of use
- After sales service
- Value for money
"Very useful equipment. Waters service is in my opinion the best from all the HPLC equipment companies."
Review date: 08 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: EMAMI LTD
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- Ease of use
- After sales service
- Value for money
Application Area:protein analysis
"This is really an excellent high throughput system. We are enjoying working on it. After sales service is good too. A rugged and robust system. The speed is matchless. However, it could be made more user friendly."
Review date: 08 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: Vrije Universiteit
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- Ease of use
- After sales service
- Value for money
Application Area:Analysis of complex bio-mass samples
"A very complete system, with possibilities currently available on the market. After finding your way around the software it is no more than turning it on and injecting for top chromatograms."
Review date: 07 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: Gedeon Richter Plc.
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- Ease of use
- After sales service
- Value for money
Application Area:pharmaceutical analysis
"Saves money on eluent and development time. Very good service. Too pricey in Hungary though compared to US prices."
Review date: 07 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: UvA
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- Ease of use
- After sales service
- Value for money
Application Area:bio oil analysis
"The UPC system is easy to use with a user friendly interface. Optimization of the gradient to get the best chromatogram was easy to do and a good chromatogram was quickly recorded. Also the other properties like pressure and detector specs were easily adjusted. The sales person also came by to see if we had questions and to give us some insights into easier ways to use the software. Overall it was easy to learn to use the software to its full extent and the technique itself has a lot of possibilities."
Review date: 07 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: Vrije Universiteit
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- Ease of use
- After sales service
- Value for money
Application Area:Complex bio-oil samples
"The software was very easy to use. Also the device itself was straight forward in its applicability. It was a good apparatus for the project."
Review date: 07 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: PTE-TTK
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- Ease of use
- After sales service
- Value for money
Application Area:Analysis of mass-transfer
"Good software and the best hardware. Bit difficult but usable software for data acquisition and data analysis. Robust, reproducible and compact hardware."
Review date: 07 Aug 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: University of Tennessee
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- Ease of use
- After sales service
- Value for money
Application Area:preparative supercritical fluid chromatography
"Excellent performance of the CO2 pump, minimize the effect of the density change of the mobile phase through the column on the chromatographic data. The software is easy to use and helps perform the necessity. The sales service is excellent, except the speed of the response. The instrument is bit expensive, but maybe worth it."
Review date: 29 May 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: Bristol Myers Squibb
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- Ease of use
- After sales service
- Value for money
Application Area:Analytical
"Very easy to order; I am very impressed that they provide me services after I received my last order. I would recommend having this for a long time."
Review date: 29 May 2013 | ACQUITY UPC² System
Status:
Reviewer Member since: 2013
Organization: Novartis
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- Ease of use
- After sales service
- Value for money
Application Area:Pharmaceutical analysis
"The UPC2 system is Waters first attempt at a SFC system that is truly theirs rather than making use of inherited equipment from previous acquisitions. It fits nicely in amongst the Acquity family of instruments and makes use of pre-existing Acquity features which familiar users will be pleased with (SFC modules integrated into Acquity Console). Running the system through MassLynx is not only straight forward but provides an easy platform for MS integration. From my experiences the hardware has been performing very well and I would highly recommend this instrument to anyone looking to do high resolution/high throughput chiral or achiral analysis."
Review date: 20 May 2013 | ACQUITY UPC² System
Convergence Chromatography with the ACQUITY UPC² System
Bring streamlined workflow, expanded selectivity, and an orthogonal technique to your laboratory.
Convergence chromatography (CC) is a broad-based, complementary analytical platform that is taking its place alongside of LC and GC as one of the three essential separation technologies for modern laboratory analysis. This technique provides another, reliable choice as an analytical platform that is orthogonal to reversed-phase LC (RPLC), while significantly streamlining the entire analytical workflow.
In convergence chromatography, the separation is achieved by manipulating the density and composition of a supercritical fluid-based mobile phase. Because of the very high diffusivity of the mobile phase, can be achieved. Additionally, the diversity of stationary phase and mobile phase (co-solvent) options provides access to the largest selectivity space available to any separation technique.
The ACQUITY UPC² System is a holistically designed UltraPerformance Convergence Chromatography (UPC²) system that utilizes liquid CO2 as the primary mobile phase. The system leverages the chromatographic principles and selectivity of normal-phase chromatography while providing the ease-of-use of RPLC, enabling you to address routine and complex separations challenges.
ACQUITY UPC² System: Discover what's been missing from your analytical toolbox
With the ACQUITY UPC² System, scientists can now separate, analyze, and understand compounds that have challenged all other LC and GC technologies including:
- Hydrophobic and chiral compounds
- Lipids
- Thermally-labile samples
- Polymers
It's also the perfect complement to MS due to its low solvent load and high resolution, narrow peaks and fast separations.
ACQUITY UPC² System Features:
- Compressed carbon dioxide (CO2), the primary mobile phase, is less costly and less toxic than liquid mobile phases or carrier gases.
- Variable volume injection delivers 0.5 µL to 10 µL as well as the ability to match column and injection volume with minimal sample loss and need to change loops.
- Higher throughput and productivity allows you to analyze more samples per day with faster re-equilibration of columns and shorter cycle times, increasing laboratory productivity.
- Co-solvent and column switching provides flexibility in method development for faster solvent screening and faster column screening.
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Product Overview
