Status:
ReviewerMember since: 2019
Organization: Eisai Pharmaceuticals India Pvt Ltd
Great results, necessary to adapt these instruments!
Application Area: Implementation of Analytical Method Development by using QbD principles
"To implement QbD concepts in analytical method development, necessary to generate the DoE in the screening experiments. Also, numerous experiments have to conduct to produce the MODR. Acquity Arc HPLC plays a pivotal role in fabricating chromatographic data without losing precision and accuracy. In addition, it is easy to operate with the Empower software. Service from the waters is easily accessible after installation in our laboratory. They will resolve the issues quickly. Overall it is a value-for-money product and helps to improve laboratory efficiency."
Status:
ReviewerMember since: 2017
Organization: Università di Torino
Good analysis in short time
Application Area:Analize organic synthesis products
"The software has medium ease of use. Waters takes care of the customer after sales"
Status:
ReviewerMember since: 2013
Organization: Merck Life Science Pvt.Ltd.
Powerful hardware components and easy to operate software for method validations.
Application Area:Pharmaceuticals
"Reproducible results with related substances analysis in APIs / Nitrosamines estmation at 5 ppb level was achieved using QDa detector"
Status:
ReviewerMember since: 2007
Organization: Aspen Pharmacare
Versatile system
Application Area:Assay and Related Substances on small molecules
"The system has 2 flow paths and allows you to perform "normal" HPLC as well as entering the space of UHPLC. With the increase in pressure limits, using columns with smaller particle size is much easier. Although the system is not a "true" UHPLC, it allows one to see the impact of system dwell volume and as a result understand the impact on your separation."
Status:
Expert ReviewerMember since: 2015
Organization: Amriya Pharmaceutical Industries
I advise scientists to buy this system
Application Area:Qualitative and quantitative and of raw materials
"Very easy to use, secured and accurate results"
Status:
ReviewerMember since: 2020
Organization: Bio Agri Mix Lp
Great results, can't live without this instrument!
Application Area:Medicinal premixes, soluble powders and other animal health products.
"Our lab currently has three ACQUITY Arc systems, with plans to add more in the immediate future to increase capacity. The systems run constantly and are critical to the business. These systems are highly effective in meeting the analysis needs of our lab, and I really don't think we could function without them. Compared to competitor HPLC systems that these replaced, the quality and integrity of the data is much higher, reproducibility was also improved. Analysts find the ACQUITY Arc system easier to use and less time is required to train users to a level of independence using the systems. For these reasons, ease of use received a 5-star rating. Post-sale service and support from the local Waters' service team is legendary! Service is prompt, thorough, courteous and compliant. Working in a regulated environment, the support after the sale is paramount and Waters' delivers exceptional support! For these reasons, both value for money, and after-sales care receive a 5-star rating. Looking at the complete package - instrument, software, support, qualification - Waters' offerings are, in my honest opinion, a fantastic value and worth every penny!"
Status:
Expert ReviewerMember since: 2015
Organization: Amriya Pharmaceutical Industries
Great and accurate results.
Application Area:Quantitative and qualitative analysis of raw materials and pharmaceutical products
"It is very easy to use and gives more control."
Status:
Expert ReviewerMember since: 2015
Organization: Amriya Pharmaceutical Industries
Very easy and accurate results.
Application Area:Quantitative and qualitative analysis
"Very sensitive and good instrument."
Status:
Expert ReviewerMember since: 2015
Organization: Amriya Pharmaceutical Industries
Great and accurate results
Application Area:Quantitative and qualitative analysis
"Very accurate and fast "
Status:
ReviewerMember since: 2019
Organization: Alexandria University, Faculty of Pharmacy
I recommend this product.
Application Area:Small molecule pharmaceuticals
"Very helpful but hard to use as it is unique and different from competitors. Being very flexible and designed for method transfer with both hardware and software adjustments and enhancements, it is a superior instrument in this regard. Automated troubleshooting and using hands instead of tools is another advantage."
Status:
ReviewerMember since: 2019
Organization: Arctic University of Norway
Efficient isolation of natural products
Application Area:Isolation of natural products
"We are using the Waters Arc in combination with a QDa and an analytical fraction collector to isolate natural products. Very easy to operate and maintain. Can be controlled by both Empower and MassLynx. Used by both researchers and students in the lab."
Status:
ReviewerMember since: 2013
Organization: Faculty of Chemistry Belgrade
Fast, reliable, highly sensitive,
Application Area:Analyze plant materials
"Acquity Arc system was a long-awaited system form Waters (for me). Robust and reliable. I have used it for a year. It's a great LC system in every way. Much better than other systems up to 600bar."
Status:
Expert ReviewerMember since: 2015
Organization: Amriya Pharmaceutical Industries
Fast and easy to use.
Application Area:Identification of active materials in samples
"It helps us to determine the amount of active materials and identifying it against standards."
Status:
Expert ReviewerMember since: 2002
Organization: University of Utah- Vascular Lab
It is a powerful system, and software is very capable, but it requires patience.
Application Area:UHPLC analysis of small biomolecules in plasma or other body fluids
"It is a wonderful system, but the Empower software has a fairly steep learning curve. I don't think that Waters provides adequate help with the software. The help dialog sometimes just brings more unanswered questions. Some of it I have had to learn by trial and error. There are classes to supposedly help, but they are expensive, and best for experienced users. If you are new, or if it has been a while since you used the software (like me), it might not be as helpful."
Status:
ReviewerMember since: 2015
Organization: St. Marks Powder
Excellent system for analysis in industrial manufacturing applications.
Application Area:Industrial chemistry
"Received the instrument to replace a bad system, and Waters did a good job in providing us with an analytical solution."
Status:
ReviewerMember since: 2018
Organization: Lanxess
Very easy to use.
Application Area:Quality control
"Product is very easy to use, is very friendly with all kind of samples and is too easy to use that even a person that does not know nothing about Analitycal chemistry can use it."
Status:
ReviewerMember since: 2018
Organization: ASOFARMA DE MEXICO SA DE CV
Trust. I have already worked with Waters HPLC systems for more than 24 yrs.
Application Area:HPLC and UPLC impurity and API analysis of pharmaceutical products in method validation
"Arc system is very useful equipment in the lab for impurity analysis with the DAD detector included, we are thinking in buy the next level QAD detector in order to complement this Arc system. The only problem that we already had is with path 1 and path 2 filters and the over pressure of the equipment."
Status:
ReviewerMember since: 2018
Organization: IBI - APRILIA
Very good results.
Application Area:Pharmaceutical products
"It'a very performing instrument and it's very easy to use. The value for money is acceptable considering the reliability of the instrument. Post sales assistance could be improved in order to achieve excellent results."
Status:
ReviewerMember since: 2018
Organization: Orofinopharmaceutical group
Great results! Transfer of analytical methods has become intuitive.
Application Area:Development of analytical methods
"I am using ACQUITY ARC System instrumentation for the development of analytical methods both in UPLC and HPLC. I am experiencing good analysis speed and excellent versatility."
Status:
ReviewerMember since: 2018
Organization: Idorsia Pharmaceuticals Ltd.
Good results for the separation of impurities
Application Area:Connection with analytical preparation unit, method development
"Effective in the method development for chiral separation methods. Trial with analytical preparation unit. It is important for us to have the possibility to inject high volumes to separate as much impurity as possible with each injection. So far good results in isolation of the impurity and further structure elucidation with MS and NMR"
Status:
ReviewerMember since: 2018
Organization: Chemconnection
Great separation poor column fitting.
Application Area:Pharmaceutical analysis
"The Arc performs as good as a (U)HPLC. Point for improvement: our Arc is equipped with a 30 cm column oven with column switch. The tubing to connect the column is not marked and gets entangled every time. Columns cannot be mounted firmly and fittings sometimes brake."
Status:
ReviewerMember since: 2018
Organization: Spin S.p.A.
Still to be evaluated
Application Area:Analysis of related substances to our API
"The instrument is easy to use and certainly offers excellent performance to the operation, but in a short time we've had so much downtime and this has not allowed us so far to appreciate an effective value in the investment made."
Status:
ReviewerMember since: 2018
Organization: Office of the Texas State Chemist
Good product. Worth recommending to colleagues.
Application Area:Analyze chemical contaminants in food and feed
"The product meets my expectations on sensitivity and selectivity. Easy for operation and maintenance."
Status:
ReviewerMember since: 2018
Organization: Patheon part of ThermoFisher Scientific
The system has been reliable and dependable.
Application Area:Analyzing API's and impurities in pharmaceutical products
"The system has been reliable and dependable for the analysis of the products that are performed on it. Consistency has been achievable while using the system. There have been very few issues with the system."
Status:
ReviewerMember since: 2018
Organization: Anokion US
Very useful.
Application Area:Analyzing proteins for multimeric state
"The instrument works well, I get reproducible results and can detect a wide range of multimeric states of proteins."
Status:
ReviewerMember since: 2018
Organization: HemPoland
Cannabis love Arc.
Application Area:Cannabinoids
"As usual, the equipment from Waters did not disappoint me. Arc has been running every day for almost two years, making a minimum of 40 injections of complex samples of hemp extracts. Not one day of downtime due to technical reasons. Thanks to the characteristics of the device and BEH columns, very quick analyzes are possible. Over 10,000 injections without a single problem. It is difficult to say how the service works, because we saw only during installation and maintenance, but probably as always are at the highest level."
Status:
ReviewerMember since: 2018
Organization: EKF Life Sciences
Overall of very good value. I would still purchase this system again.
Application Area:Fermentation catabolite analysis
"This UHPLC has been a solid and reliable unit. We are still learning all of the capabilities of the Empower software, but sometimes trying to match integration techniques against other system results is not so easy. We do not use this daily, but it is easy to start up and maintain."
Status:
ReviewerMember since: 2018
Organization: Hyland's
Nice tool for method development.
Application Area:Analyse pharmaceutical samples
"Easy to use, good for method development since it has both HPLC and UPLC capabilities."
Status:
ReviewerMember since: 2018
Organization: Max Zeller Söhne AG
With exception to the above mentioned restrictions we are satisfied with the system
Application Area:Analyse small molecules in plants, plant extracts and herbal medicinal products
"the arc system works very well. resolution is higher than on the old Agilent systems we used before. Therefore we have had surprizes with transfer of older methods to the Arc system: sometimes you will find more peaks then before, which can cause problems in stability research. We are obliged to define identity of those peaks. The possibility to use the System with different dwell volumes is interesting."
Status:
ReviewerMember since: 2018
Organization: Indena SpA
With 2 out of 3 instruments a nasty bug is there "missed injection", not yet solved
Application Area:Pharmaceutical analysis
"basically it hits the targets, however 2 out of 3 instrument we purchased show a frequent problem of "missed injection", with a nasty impact on throughput and regulatory."
Status:
ReviewerMember since: 2018
Organization: Pennsylvania State University
The ACQUITY Arc System proves itself to be a dependable and consistent HPLC system.
Application Area:Purification and analysis of modified and non-modified oligonucleotides
"As with past waters systems, the ACQUITY Arc System proves to be a top of the line, dependable and consistent HPLC system. While teaching new users may be a bit tricky due to how the Method and Method Sets work, once the user gets a hang of it, it is fairly easy to use. We also purchased an auto-sampler with our system which has allowed made it significantly easier to purify our samples without having to sit next to the HPLC. Overall, for labs that use HPLC this is a smart buy especially for the potential upgrades and extras you can purchase."
Status:
ReviewerMember since: 2018
Organization: Stada Arzneimitel AG
We are really satisfied at the moment.
Application Area:Methode Development and impurity profiling
"We are still in test phase. But the great benefit at this time is the easy switch between the long and the short flow way. Also the use of the QdA Dating our method development is an absolute benefit."
Status:
ReviewerMember since: 2018
Organization: Bio Agri Mix LP
Great HPLC/UPLC, chemists line up to use it.
Application Area:Pharmaceutical analysis
"We are using the ARC to replace older HPLC systems. It is more reliable and robust than those systems. In addition, it serves as extra UHPLC capacity in our lab. There are always lineups of chemists wanting to use the 2 ARCs we have for their analyses."
Status:
ReviewerMember since: 2018
Organization: ZOETIS
Excellent
Application Area:SEC methods
"Easy to use. Good customer service in case of issue. Really fast through irequest. Personalized training very efficient."
Status:
ReviewerMember since: 2018
Organization: University of Delaware
Plugs often, many service calls required. Overall unhappy.
Application Area:Organic chemistry
"This instrument requires frequent service calls. The sensitivity is also low compared to similar Agilent instruments. Overall, I would not buy this again."
Status:
ReviewerMember since: 2018
Organization: Galenica AB
Good instrument for QC
Application Area:Analysis of small molecules
"Robust instrument with the possibility to run both HPLC and UPLC. Easy and fast access to service"
Status:
ReviewerMember since: 2018
Organization: Akorn Pharmaceuticals
The instrument is a must for any R&D lab. We like it better than the H class
Application Area:Method development and analysis of stability samples
"The instrument is very user friendly. We have had no issues to date."
Status:
ReviewerMember since: 2018
Organization: J Strickland & Co.
Just what the doctor ordered!
Application Area:Cosmetic drug manufacturer
"Outstanding product that promises to cut down product evaluation time and increase productivity"
Status:
ReviewerMember since: 2018
Organization: Anokion
Excellent system, very flexible.
Application Area:Peptide and protein analysis
"Excellent system, highly robust, consistent values from run to run."
Status:
ReviewerMember since: 2018
Organization: Sterling S.p.A.
Good instrument. To be improved for the problem of sample manager purge.
Application Area:Analysis of API , Quality Control Lab
"Good results, good repeatability. Good counter-pressure of the system. Acquity Arc requires long preparation times greater than HPLC Alliance. The preparation of instrument is very complex for direct analysis. I observed many cases of air bubbles originating from sample manager purge. These bubbles affect the volume of injection, so affect the value of area. This is a problem in case of the related substances and assay analysis."
Status:
ReviewerMember since: 2018
Organization: Kanyos Bio
Great results! Wish the software and output were easier
Application Area:Analytical development
"Thank you! The Waters instruments are solid but the software could more user friendly."
Status:
ReviewerMember since: 2018
Organization: GSK Vaccines
Great way to improve HPLC methods without switching to UPLC completely.
Application Area:Analyze proteins in vaccines intermediates and final products
"We were transferring different protein analyzing methods (RP and SEC) into our lab which were implemented on the Arc systems. The methods originated from HPLCs. The systems work very well and implementing the method instantly showed better resolution. With these systems we have room for optimizing the methods because we can achieve better results in a much shorter run time utilizing the Arc systems. We are so far very satisfied."
Status:
ReviewerMember since: 2018
Organization: Reckitt Benckiser
Grate value
Application Area:Pharmaceutical Quality Control and Method development
"It is a very easy equipment to use. with high precision and accurate results."
Status:
ReviewerMember since: 2018
Organization: OHSU
Great sensitivity, consistent results.
Application Area:Protein quality assessment
"A quality product with a steep learning curve. Definitely worth figuring out how to set up all of the automation features that come included in empower."
Status:
ReviewerMember since: 2018
Organization: Alnylam Pharmaceuticals
Great gradient precision, flow path flexibility, critical equipment for success
Application Area:Oligonucleotide Characterization
"We're able to successfully deploy this system to run analytical up to semipreparative scale with high fraction recovery using the WFMA. The pump with the split flow path enables us to adjust our gradient delays at analytical and semi-preparative scales and move between scales flawlessly. The 9500 psi threshold is suitable for our needs and flow rate demands. Overall, it has been an excellent purchase."
Status:
ReviewerMember since: 2018
Organization: AGENCIA ESPAÑOLA DE MEDICAMENTOS Y PRODUCTOS SANITARIOS
Good equipment.
Application Area:analyze raw materials
"It is easy to use if you have used an Aquity HClass."
Status:
ReviewerMember since: 2018
Organization: Gentec
Ok, it may be expensive, but is robust.
Application Area:Fine Chemicals analysis
"Good equipment, robust and solid. The software is a litlle bit too hard, but is ok. The relationship between features and prices is not the better and the footprint is too big for the standard table lab."
Status:
ReviewerMember since: 2018
Organization: Aura Biosciences
Very nice upgrade from HPLC. Love it!
Application Area:Protein and peptide analysis
"Easy to use, smooth transition from waters HPLC, great value, and flexibility (we got 3 detectors)."
Status:
ReviewerMember since: 2018
Organization: Kop Coat, Inc.
If I didn't have a Waters instrument, I would be pushing quite hard to get one!
Application Area:Wood Coatings
"The capabilities of his instrument is absolutely fantastic! I can rely on the results and I am astonished by how quickly I can analyze a batch of samples through multiple methods. The four pump system really helps with switching from different mobile phases from method to method."
Status:
ReviewerMember since: 2018
Organization: Thermo Fisher Scientific
Great equipment, for a lab bridging the gap between legacy HPLC and improved UHPLC
Application Area:Analyze small molecule/large molecule pharmaceuticals by HPLC/ development methods for UHPLC
"Product has been very effective for pharmaceutical testing allowing use to test legacy HPLC methods, but also develop and transfer methods using newer column technologies and higher pressures. Use of choice between two physical flow paths allows use easy choice of optimized system volume. System works well with Empower and has useful features, (only draw back is I prefer to have a screen on the system for setup and quick shut down in an emergency without having a laptop with me always). Equipment is easy to set up, and has shown it self to be robust. Waters local representatives and troubleshooting personnel have been very helpful with any issues or questions we have had after purchase. Having already had Empower, Alliance and H-Class systems this equipment fits easily into our knowledge base. System is a little high priced compared to a equivalent system by other vendors."
Status:
ReviewerMember since: 2018
Organization: Orit Laboratories LLC
Very reproducible results
Application Area:Pharmaceuticals
"Comparison study with HPLC and UPLC was performed and Arc system found to be working perfectly mimicking HPLC analysis and to some extent UPLC analysis."
Status:
ReviewerMember since: 2018
Organization: Tulex Pharmaceuticals
Good, reproducible results.
Application Area:Quantifying amounts of substance within samples
"Results are reproducible and accurate. However, the ARC can only be controlled from one computer, which can be a bit cumbersome sometimes."
Status:
ReviewerMember since: 2016
Organization: Missouri Analytical Labs
A helpful tool for method transfer but would like to see pressure max at 12,000 psi
Application Area:Method Transfer
"The Waters Arc system is ideal for transferring methods between instruments when instrument-to-instrument variables, such as dwell volume, play a major role. We are the receiving lab for a great number of methods in which we have minimal to no communication with the transferring lab. The Arc allows us to simulate a wide variety of instrument types in order to best replicate the transferring labs setup without knowing the type of LC they use. However, I was disappointed that when they advertised it as "UHPLC" that the max pressure is <10,000 psi."
Status:
ReviewerMember since: 2011
Organization: IPN-ENCB
Proteins peptide quality assurance
Application Area:Protein (Antibodies) and Peptide ID & QA
"It's a very confinable, robust performance and a excellence technical support, our best selection in LC analysis for protein and peptide molecules "
Status:
ReviewerMember since: 2014
Organization: Merck Pharmaceuticals (Private) Limited
Very effective and user friendly if you are trained.
Application Area:Chemical Analysis
"Yes, it is very effective especially in research & development work."
The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays.
The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables.
Get seamless and efficient transfer, adjustment, or improvement of methods from any LC platform without compromise in method integrity or changes to validated gradient tables.
The ACQUITY Arc System is enabled by Arc Multi-flow path technology, novel technology that enables the user to easily switch between HPLC and UHPLC operation by selecting the dwell volume that best fits the column separation. System reliability and robustness ensures product consistency and compliance with regulatory guidelines, all while minimizing downtown and inefficiencies.
With the ACQUITY Arc System, maximize productivity through combining system dispersion characteristics with efficient and rapid 2.x um UHPLC separations. Or, accommodate larger, 3.0 - 5.0 um particles. This provides the flexibility to support a wide-range of LC applications.
Get an LC-MS solution that's as easy to use as photodiode array detection. The ACQUITY Arc System is fully compatible with the ACQUITY QDa Detector, supporting routine analysis applications and expanding the information you can get from your system using the same Empower Software.
Features: