Thermo Scientific™ Acclaim™ Trinity P1 LC Column by Thermo Fisher Scientific

his new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content concurrently or independently.

The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.


Acclaim Trinity P1 LC Column Features:

• Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange
• Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH and organic solvent
• Ideal selectivity for simultaneous separation of basic, neutral, and acidic analytes
• Separation of hydrophilic ionic and ionizable analytes without ion-pairing reagents

Applications:

• Active Pharmaceutical Ingredients (API) and counterions (cations or anions).
• Screening of pharmaceutical counterions. Both UV and an ELS detector, in series, are required for simultaneous determination of both drug substances and counterions.
• Mixture of acidic and basic drug substances and respective counterions.
• Drug substances: of acidic, basic and neutral mixtures.
• High throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.

Column Details:

• Chemistry: SCX, WAX and RP Mixed-Mode
• Length: 50, 100, 150 mm
• ID: 2.1, 3.0 mm