The Acclaim® Mixed-Mode WCX-1 is a novel, high-efficiency, silica-based column, manufactured by bonding a specially designed proprietary ligand with both hydrophobic and weak cation-exchange properties. Selectivity of ionizable and neutral compounds can be controlled independently or simultaneously by tuning mobile phase ionic strength, pH or organic modifier. This column therefore can separate using multiple separation modes: reversed phase, cation exchange, and normal phase/HILIC.The adjustable selectivity of the Mixed-Mode WCX-1 makes it an ideal column for secondary methods development since the selectivity is orthogonal to C18 columns and weak anion-exchange (WAX) columns. The Acclaim Mixed-Mode WCX-1 columns novel column chemistry offers multiple retention mechanisms, including RPL...Read more
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